Growth Arrest and DNA-Damage-Inducible Gamma Interacting Protein 1 Recombinant Protein | GADD45GIP1 recombinant protein

Recombinant Human Growth Arrest and DNA-Damage-Inducible Gamma Interacting Protein 1

Cat. Num. AAA144896

• Gene Names: GADD45GIP1; PRG6; CRIF1; PLINP; CKBBP2; Plinp1; MRP-L59; PLINP-1; CKbetaBP2
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Growth Arrest and DNA-Damage-Inducible Gamma Interacting Protein 1; Recombinant Human Growth Arrest and DNA-Damage-Inducible Gamma Interacting Protein 1; GADD45GIP1 Human; Growth Arrest and DNA-Damage-Inducible Gamma Interacting Protein 1 Human Recombinant; Growth arrest and DNA-damage-inducible gamma interacting protein 1; PRG6; CRIF1; PLINP-1; KBBP2; Plinp1; Papillomavirus L2-interacting nuclear protein 1; CKII beta-associating protein; CR6-interacting factor 1; p53-responsive gene 6 protein; CKII beta binding protein 2; growth arrest and DNA damage-inducible proteins-interacting protein 1; papillomavirus L2 interacting nuclear protein 1; PLINP1; GADD45GIP1 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: The GADD45GIP1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 0.2M NaCl and 40% glycerol.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MPRWQLGPRY AAKQFARYGA ASGVVPGSLW PSPEQLRELE AEEREWYPSL ATMQESLRVK QLAEEQKRRE REQHIAECMA KMPQMIVNWQ QQQRENWEKA QADKERRARL QAEAQELLGY QVDPRSARFQ ELLQDLEKKE RKRLKEEKQK RKKEARAAAL AAAVAQDPAA SGAPSS
• Sequence Length: 222

Related Product Information for GADD45GIP1 recombinant protein

Description: GADD45GIP1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 196 amino acids (48-222) and having a molecular mass of 22.6 kDa.GADD45GIP1 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: GADD45GIP1 is a nuclear protein which takes part in apoptosis control. GADD45GIP1 is expressed in several tissues, such as heart, thyroid, trachea, kidney, ovary, pancreas, testis and stomach and acts as a negative regulator of G1 to S phase cell cycle production by collaborating with GADD45 proteins to inhibit the activity of cyclin-dependent kinases.

Product Categories/Family for GADD45GIP1 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; DNA-Damage Protein

NCBI and Uniprot Product Information

• NCBI GI #: 31543415
• NCBI GeneID: 90480
• NCBI Accession #: NP_443082.2
• NCBI GenBank Nucleotide #: NM_052850.3
• UniProt Accession #: Q8TAE8; Q8IVM3; Q8TE51; Q969P9; Q9BSM6
• Molecular Weight: 25,384 Da
• NCBI Official Full Name: growth arrest and DNA damage-inducible proteins-interacting protein 1
• NCBI Official Synonym Full Names: growth arrest and DNA-damage-inducible, gamma interacting protein 1
• NCBI Official Symbol: GADD45GIP1
• NCBI Official Synonym Symbols: PRG6; CRIF1; PLINP; CKBBP2; Plinp1; MRP-L59; PLINP-1; CKbetaBP2
• NCBI Protein Information: growth arrest and DNA damage-inducible proteins-interacting protein 1; 39S ribosomal protein L59, mitochondrial; CKII beta binding protein 2; CKII beta-associating protein; CR6 interacting factor 1; growth arrest- and DNA damage-inducible GADD45G-interacting protein; p53-responsive gene 6 protein; papillomavirus L2 interacting nuclear protein 1
• UniProt Protein Name: Growth arrest and DNA damage-inducible proteins-interacting protein 1
• Protein Family: Growth arrest and DNA damage-inducible protein
• UniProt Gene Name: GADD45GIP1
• UniProt Synonym Gene Names: MRPL59; PLINP1; PRG6; MRP-L59; CRIF1; PLINP; PLINP-1
• UniProt Entry Name: G45IP_HUMAN

NCBI Description

This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]

Uniprot Description

GADD45GIP1: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. Interacts with GADD45A, GADD45B and GADD45G. Interacts with NR4A1 via the NR4A1 AB domain. Interacts with the human papilloma virus type 16 (HPV 16) minor capsid protein L2. Down-regulated by p53/TP53 in apoptotic cells. Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer.

Protein type: Cell cycle regulation; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: mitochondrion; mitochondrial matrix; nucleus

Molecular Function: protein binding

Biological Process: viral reproduction; mitochondrial translation; organelle organization and biogenesis; cell cycle