Testing Data
Rabbit ITM2C Polyclonal Antibody | anti-ITM2C antibody
Anti-ITM2C Antibody
Reactivity
Human. Predicted: Mouse, Rat.
Applications
ELISA, Immunohistochemistry
Purity
Affinity purified
Synonyms
ITM2C; Polyclonal Antibody; Anti-ITM2C Antibody; anti-ITM2C antibody
Host
Rabbit
Reactivity
Human. Predicted: Mouse, Rat.
Clonality
Polyclonal
Purity/Purification
Affinity purified
Form/Format
Liquid
Concentration
100ug/100ul (varies by lot)
Sequence Length
267
Applicable Applications for anti-ITM2C antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes
ELISA titer: 1:20,000-1:80,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user.
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user.
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
Rabbit polyclonal ITM2C (1) antibody was raised against a recombinate human ITM2C protein 92-227aa (BC025742).
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Testing Data
Testing Data
References
(1) Yoshida,T., Kato,K., Yokoi,K. et al. Association of genetic variants with hemorrhagic stroke in Japanese individuals. Int. J. Mol. Med. 25 (4), 649-656 (2010).
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
25,921 Da
NCBI Official Full Name
ITM2C
UniProt Protein Name
Integral membrane protein 2C
Protein Family
UniProt Gene Name
ITM2C
UniProt Entry Name
ITM2C_HUMAN
Uniprot Description
ITM2C: Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C- terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation. Belongs to the ITM2 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q37
Cellular Component: Golgi apparatus; lysosomal membrane; perinuclear region of cytoplasm; lysosome; plasma membrane; integral to membrane
Molecular Function: protein binding; beta-amyloid binding; ATP binding
Biological Process: neuron differentiation
Similar Products
Product Notes
The ITM2C itm2c (Catalog #AAA416824) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-ITM2C Antibody reacts with Human. Predicted: Mouse, Rat. and may cross-react with other species as described in the data sheet. AAA Biotech's ITM2C can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). ELISA titer: 1:20,000-1:80,000 Immunohistochemistry: 1:100-1:500 Optimal dilutions/concentrations should be determined by the end user. Researchers should empirically determine the suitability of the ITM2C itm2c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ITM2C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
