Rat frizzled homolog 8 (Drosophila) ELISA Kit | FZD8 elisa kit
Rat Frizzled-8, FZD8 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
FZD8: Receptor for Wnt proteins. Component of the Wnt-Fzd- LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome- sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. Belongs to the G-protein coupled receptor Fz/Smo family.
Protein type: GPCR, Fz/Smo family; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral
Cellular Component: Golgi apparatus; integral to membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; Wnt receptor activity; ubiquitin protein ligase binding; receptor binding; PDZ domain binding
Biological Process: positive regulation of JNK activity; G-protein coupled receptor protein signaling pathway; Wnt receptor signaling pathway; multicellular organismal development; T cell differentiation in the thymus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; Wnt receptor signaling pathway through beta-catenin; angiogenesis; negative regulation of transcription from RNA polymerase II promoter; signal transduction
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Product Notes
The Rat FZD8 fzd8 (Catalog #AAA9341055) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9341055 ELISA Kit recognizes Rat FZD8. It is sometimes possible for the material contained within the vial of "frizzled homolog 8 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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