Phospholemman (FXYD1) Recombinant Protein | FXYD1 recombinant protein

Recombinant Bovine Phospholemman (FXYD1), partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Phospholemman (FXYD1); Recombinant Bovine Phospholemman (FXYD1); partial; FXYD1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 92

• Species: Bovine
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for FXYD1 recombinant protein

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This protein is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5 UTR sequences have been described in the literature.

NCBI and Uniprot Product Information

• NCBI GI #: 115497296
• NCBI GeneID: 616139
• NCBI Accession #: NP_001069878.1
• NCBI GenBank Nucleotide #: NM_001076410.1
• UniProt Accession #: Q3SZX0
• Molecular Weight: 10,447 Da
• NCBI Official Full Name: phospholemman
• NCBI Official Synonym Full Names: FXYD domain containing ion transport regulator 1
• NCBI Official Symbol: FXYD1
• NCBI Protein Information: phospholemman
• UniProt Protein Name: Phospholemman
• Protein Family: Phospholemman
• UniProt Gene Name: FXYD1

Uniprot Description

Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na+ out of the cell and K+ into the cell (PubMed:12657675). Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated (). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (). Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone ().