Follicle-stimulating hormone receptor (Fshr) Recombinant Protein | Fshr recombinant protein
Recombinant Rat Follicle-stimulating hormone receptor (Fshr)
NCBI and Uniprot Product Information
NCBI Description
testicular receptor for follicle stimulating hormone; stimulates adenylyl cyclase activity [RGD, Feb 2006]
Uniprot Description
FSHR: Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1); also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS). OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral
Cellular Component: cell surface; cell; integral to membrane; plasma membrane; endosome
Molecular Function: G-protein coupled receptor activity; protein binding; peptide hormone binding; follicle-stimulating hormone receptor activity
Biological Process: regulation of estrogen receptor signaling pathway; follicle-stimulating hormone signaling pathway; primary ovarian follicle growth; positive regulation of estrogen receptor signaling pathway; locomotory behavior; regulation of chromosome organization and biogenesis; uterus development; G-protein signaling, adenylate cyclase activating pathway; ovulation cycle process; regulation of osteoclast differentiation; sperm chromatin condensation; ovarian follicle development; negative regulation of bone resorption; neurite development; regulation of protein amino acid phosphorylation; regulation of hormone metabolic process; cellular water homeostasis; spermatogenesis, exchange of chromosomal proteins; male gonad development; Sertoli cell proliferation; transcytosis; Sertoli cell development; G-protein signaling, coupled to cAMP nucleotide second messenger; regulation of MAPKKK cascade; regulation of systemic arterial blood pressure; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); spermatogenesis; G-protein signaling, adenylate cyclase inhibiting pathway; spermatid development
Research Articles on Fshr
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Product Notes
The Fshr fshr (Catalog #AAA952923) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 18-692. The amino acid sequence is listed below: CHHWLCHCSN RVFLCQDSKV TEIPTDLPRN AIELRFVLTK LRVIPKGSFA GFGDLEKIEI SQNDVLEVIE ADVFSNLPKL HEIRIEKANN LLYINPEAFQ NLPSLRYLLI SNTGIKHLPA VHKIQSLQKV LLDIQDNINI HIVARNSFMG LSFESVILWL SKNGIEEIHN CAFNGTQLDE LNLSDNNNLE ELPNDVFQGA SGPVILDISR TKVHSLPNHG LENLKKLRAR STYRLKKLPN LDKFVTLMEA SLTYPSHCCA FANLKRQISE LHPICNKSIL RQDIDDMTQI GDQRVSLIDD EPSYGKGSDM MYNEFDYDLC NEVVDVTCSP KPDAFNPCED IMGYNILRVL IWFISILAIT GNTTVLVVLT TSQYKLTVPR FLMCNLAFAD LCIGIYLLLI ASVDIHTKSQ YHNYAIDWQT GAGCDAAGFF TVFASELSVY TLTAITLERW HTITHAMQLE CKVQLRHAAS VMVLGWTFAF AAALFPIFGI SSYMKVSICL PMDIDSPLSQ LYVMALLVLN VLAFVVICGC YTHIYLTVRN PTIVSSSSDT KIAKRMATLI FTDFLCMAPI SFFAISASLK VPLITVSKAK ILLVLFYPIN SCANPFLYAI FTKNFRRDFF ILLSKFGCYE MQAQIYRTET SSATHNFHAR KSHCSSAPRV TNSYVLVPLN HSSQN. It is sometimes possible for the material contained within the vial of "Follicle-stimulating hormone receptor (Fshr), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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