Fyn Related Kinase Recombinant Protein | FRK recombinant protein

Recombinant Fyn Related Kinase (FRK)

Cat. Num. AAA2029908

• Gene Names: FRK; GTK; RAK; PTK5
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: >95%
• Synonyms: Fyn Related Kinase; Recombinant Fyn Related Kinase (FRK); FRK recombinant protein

• Host: Host: E Coli; Source: Prokaryotic expression
• Purity/Purification: >95%
• Form/Format: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Sequence: The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.; VDQWEID RNSIQLLKRL GSGQFGEVWEGLWNNTTPVA VKTLKPGSMD PNDFLREAQI MKNLRHPKLI QLYAVCTLEDPIYIITELMR HGSLQEYLQN DTGSKIHLTQ QVDMAAQVAS GMAYLESRNYIHRDLAARNV LVGEHNIYKV ADFGLARVFK VDNEDIYESR HEIKLPVKWTAPEAIRSNKF SIKSDVWSFG ILLYEIITYG KMPYSGMTGA QVIQMLAQNYRLPQPSNCPQ QFYNIMLECW NAEPKERPTF ETLRWKLEDY F
• Sequence Length: 505

• Applicable Applications for FRK recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Predicted Molecular Mass: 34.8KDa
• Accurate Molecular Mass (KD): 35kDa
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Expression System: Prokaryotic expression
• Tag: two N-terminal tags, his-tag and T7 tag
• Organism Species: Homo sapiens (Human)
• Fragment: Val234~Phe491
• Usage: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 119568626
• NCBI GeneID: 2444
• Molecular Weight: 41,980 Da
• NCBI Official Full Name: fyn-related kinase
• NCBI Official Synonym Full Names: fyn-related Src family tyrosine kinase
• NCBI Official Symbol: FRK
• NCBI Official Synonym Symbols: GTK; RAK; PTK5
• NCBI Protein Information: tyrosine-protein kinase FRK
• UniProt Protein Name: Tyrosine-protein kinase FRK
• Protein Family: Tyrosine-protein kinase
• UniProt Gene Name: FRK
• UniProt Synonym Gene Names: PTK5; RAK
• UniProt Entry Name: FRK_HUMAN

NCBI Description

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]

Uniprot Description

FRK: a tyrosine kinase of the Src family. Expressed in cell lines derived from tissues of lymphoid, brain, breast, colon and bladder origin. A nuclear protein that may function during G1 and S phase of the cell cycle to suppress growth.

Protein type: Tumor suppressor; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Kinase, protein; EC 2.7.10.2; TK group; Src family

Chromosomal Location of Human Ortholog: 6q21-q22.3

Cellular Component: extrinsic to internal side of plasma membrane; cytoplasm; intracellular; nucleus

Molecular Function: protein binding; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding

Biological Process: negative regulation of cell proliferation; cell migration; innate immune response; cell differentiation; actin cytoskeleton organization and biogenesis; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation