Human forkhead box F1 ELISA Kit | FOXF1 elisa kit
Human Forkhead box protein F1, FOXF1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008]
Uniprot Description
FOXF1: Probable transcription activator for a number of lung- specific genes. Defects in FOXF1 are the cause of alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV). ACDMPV is a rare malformation due to abnormal development of the capillary vascular system in the lungs. Histologically, it is characterized by failure of formation and ingrowth of alveolar capillaries, medial muscular thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular, gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn.
Protein type: Transcription factor; DNA-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16q24
Cellular Component: transcription factor complex; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; DNA binding; sequence-specific DNA binding
Biological Process: transcription from RNA polymerase II promoter; extracellular matrix organization and biogenesis; negative regulation of mast cell degranulation; heart development; positive regulation of transcription, DNA-dependent; establishment of epithelial cell polarity; negative regulation of transcription from RNA polymerase II promoter; lateral mesodermal cell differentiation; cell-cell adhesion; embryonic digestive tract morphogenesis; pancreas development; positive regulation of mesenchymal cell proliferation; regulation of smooth muscle cell differentiation; embryonic foregut morphogenesis; detection of wounding; vasculogenesis; blood vessel development; smoothened signaling pathway; somitogenesis; in utero embryonic development; respiratory tube development; morphogenesis of a branching structure; gut development; negative regulation of inflammatory response; midgut development; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; embryonic ectodermal gut morphogenesis; determination of left/right symmetry; alveolus development; lung development; positive regulation of cell migration
Disease: Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Research Articles on FOXF1
Similar Products
Product Notes
The Human FOXF1 foxf1 (Catalog #AAA9332765) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9332765 ELISA Kit recognizes Human FOXF1. It is sometimes possible for the material contained within the vial of "forkhead box F1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
