Fish Multidrug Resistance Protein 1A (MDR1A) ELISA Kit | MDR1A elisa kit
Fish Multidrug Resistance Protein 1A (MDR1A) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a p-glycoprotein which actively transports a variety of hydrophobic amphipathic drugs and plays a major role in the blood-brain barrier permeability of certain drugs. [provided by RefSeq, Jul 2008]
Uniprot Description
ABCB1: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Interacts with PSMB8.
Protein type: Cell adhesion; EC 3.6.3.44; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family
Chromosomal Location of Human Ortholog: 5 A1|5 3.43 cM
Cellular Component: apical part of cell; apical plasma membrane; brush border membrane; cell surface; extracellular exosome; integral component of membrane; intercellular canaliculus; membrane; plasma membrane
Molecular Function: ATP binding; ATPase activity; ATPase activity, coupled; ATPase activity, coupled to transmembrane movement of substances; ceramide-translocating ATPase activity; hydrolase activity; nucleotide binding; phosphatidylcholine-translocating ATPase activity; phosphatidylethanolamine-translocating ATPase activity; xenobiotic transmembrane transporting ATPase activity
Biological Process: carbohydrate export; ceramide translocation; daunorubicin transport; drug export; drug transmembrane transport; drug transport; drug transport across blood-brain barrier; establishment of blood-retinal barrier; G2/M transition of mitotic cell cycle; hormone transport; intestinal absorption; phospholipid translocation; positive regulation of anion channel activity; positive regulation of response to drug; regulation of chloride transport; regulation of intestinal absorption; regulation of response to osmotic stress; stem cell proliferation; transmembrane transport; transport
Research Articles on MDR1A
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Product Notes
The Fish MDR1A abcb1a (Catalog #AAA9396963) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9396963 ELISA Kit recognizes Fish MDR1A. It is sometimes possible for the material contained within the vial of "Multidrug Resistance Protein 1A (MDR1A), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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