Human four and a half LIM domains 2 ELISA Kit | FHL2 elisa kit
Human Four and a half LIM domains protein 2, FHL2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011]
Uniprot Description
FHL2: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.
Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q12.2
Cellular Component: nucleoplasm; focal adhesion; M band; Z disc; nucleus; actin cytoskeleton
Molecular Function: identical protein binding; protein binding; androgen receptor binding; zinc ion binding; transcription coactivator activity; transcription factor binding
Biological Process: osteoblast differentiation; transcription, DNA-dependent; atrial cardiac muscle cell development; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; ventricular cardiac muscle cell development; response to hormone stimulus; negative regulation of transcription from RNA polymerase II promoter; cellular lipid metabolic process; negative regulation of apoptosis
Research Articles on FHL2
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Product Notes
The Human FHL2 fhl2 (Catalog #AAA9335021) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9335021 ELISA Kit recognizes Human FHL2. It is sometimes possible for the material contained within the vial of "four and a half LIM domains 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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