FGF4 recombinant protein

FGF4 Protein, Human, Recombinant

Cat. Num. AAA8122005

• Gene Names: FGF4; HST; KFGF; HST-1; HSTF1; K-FGF; HBGF-4
• Purity: >90% as determined by SDS-PAGE
• Synonyms: FGF4; FGF4 Protein; Human; Recombinant; Human FGF4 Protein; HBGF-4 Protein; HST Protein; HST-1 Protein; HSTF1 Protein; K-FGF Protein; KFGF Protein; fibroblast growth factor 4; FGF4 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH8.0. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Ser54-Leu206

• Species: Human
• Predicted N Terminal: Met
• Tag: Native
• Protein Construction: A DNA sequence encoding the human FGF4 (NP_001998.1)(Ser54-Leu206) was expressed.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for FGF4 recombinant protein

Background: FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specification of both blood and skeletal muscle lineages. Fibroblast growth factor 4 (FGF4) signaling induces differentiation from embryonic stem cells (ESCs) via the phosphorylation of downstream molecules such as mitogen-activated protein kinase/extracellular signal-related kinase (MEK) and extracellular signal-related kinase 1/2 (ERK1/2). Fibroblast Growth Factor 4 (FGF-4) could not only increase the proliferation of bone marrow mesenchymal stem cells (BMSCs), but also induce BMSCs into hepatocyte-like cells in vitro. FGF4 transduced BMSCs contributed to liver regeneration might by the transplanted microenvironment. The FGF4-bFGF BMSCs thus can enhance the survival of the transplanted cells, diminish myocardial fibrosis, promote myocardial angiogenesis, and improve cardiac functions.

NCBI and Uniprot Product Information

• NCBI GI #: 4503701
• NCBI GeneID: 2249
• NCBI Accession #: NP_001998.1
• NCBI GenBank Nucleotide #: NM_002007.2
• UniProt Accession #: P08620; B7U994; AAB21430
• Molecular Weight: 12,237 Da
• NCBI Official Full Name: fibroblast growth factor 4
• NCBI Official Synonym Full Names: fibroblast growth factor 4
• NCBI Official Symbol: FGF4
• NCBI Official Synonym Symbols: HST; KFGF; HST-1; HSTF1; K-FGF; HBGF-4
• NCBI Protein Information: fibroblast growth factor 4; FGF-4; HSTF-1; fibroblast growth factor 4 splice isoform; heparin secretory transforming protein 1; heparin secretory-transforming protein 1; heparin-binding growth factor 4; human stomach cancer, transforming factor from FGF-r
• UniProt Protein Name: Fibroblast growth factor 4
• Protein Family: Fibroblast growth factor
• UniProt Gene Name: FGF4
• UniProt Synonym Gene Names: HST; HSTF1; KS3; FGF-4; HST; HST-1; HSTF-1; HBGF-4
• UniProt Entry Name: FGF4_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008]

Uniprot Description

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.