FYVE, RhoGEF and PH domain-containing protein 1 (Fgd1) Recombinant Protein | Fgd1 recombinant protein

Recombinant Mouse FYVE, RhoGEF and PH domain-containing protein 1 (Fgd1) , partial

• Gene Names: Fgd1; ZFYVE3
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: FYVE; RhoGEF and PH domain-containing protein 1 (Fgd1); Recombinant Mouse FYVE; partial; Fgd1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 960

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Fgd1 recombinant protein

FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK
JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.

NCBI and Uniprot Product Information

• NCBI GI #: 31982367
• NCBI GeneID: 14163
• NCBI Accession #: NP_032027.2
• NCBI GenBank Nucleotide #: NM_008001.4
• UniProt Accession #: P52734; Q921L2
• Molecular Weight: 106,365 Da
• NCBI Official Full Name: FYVE, RhoGEF and PH domain-containing protein 1
• NCBI Official Synonym Full Names: FYVE, RhoGEF and PH domain containing 1
• NCBI Official Symbol: Fgd1
• NCBI Official Synonym Symbols: ZFYVE3
• NCBI Protein Information: FYVE, RhoGEF and PH domain-containing protein 1
• UniProt Protein Name: FYVE, RhoGEF and PH domain-containing protein 1
• Protein Family: FYVE, RhoGEF and PH domain-containing protein
• UniProt Gene Name: Fgd1
• UniProt Synonym Gene Names: Rho/Rac GEF

NCBI Description

This gene encodes a member of family of Rho-specific guanine nucleotide exchange factors. Rho-specific guanine nucleotide exchange factors catalyze the exchange of GDP for GTP and activate small GTPases, which function as molecular switches in signaling. This protein specifically binds cell division cycle 42, a Rho (Ras homology) GTPase. Investigations in mouse suggest that this protein is important for skeletal mineralization and for regulating the actin cytoskeleton. In humans, mutations in this gene are associated with faciogenital dysplasia, also known as Aarskog-Scott syndrome. [provided by RefSeq, Mar 2014]

Uniprot Description

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.