FCRL1 recombinant protein

FCRL1 Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8120844

• Gene Names: FCRL1; FCRH1; IFGP1; IRTA5; CD307a
• Purity: >98% as determined by SDS-PAGE
• Synonyms: FCRL1; FCRL1 Protein; Human; Recombinant (His Tag); Human FCRL1/FCRH1 Protein (His Tag); CD307a Protein; FCRH1 Protein; IFGP1 Protein; IRTA5 Protein; Fc receptor-like 1; FCRL1 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >98% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4, 1mM EDTA. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Asn303

• Species: Human
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Ala 17
• Tag: C-His
• Protein Construction: A DNA sequence encoding the human FCRL1 (NP_443170.1) extracellular domain (Met 1-Asn 303) was fused with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for FCRL1 recombinant protein

Background: Fc receptor-like protein 1, also known as FcR-like protein 1, Fc receptor homolog 1, IFGP family protein 1, Immune receptor translocation-associated protein 5 and FCRL1, is a single-pass type I membrane protein which contains threeIg-like C2-type (immunoglobulin-like) domains. It is a cell-surface membrane protein belonging to FCRL family and is preferentially expressed on B cells. FCRL1 is primarily expressed in secondary lymphoid tissues by mature subsets of B cells. It is detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. FCRL1 is specifically expressed by mature B lineage cells with higher expression in naive versus memory B cells (at protein level). Human Fc receptor-like molecules (FCRL1, FCRL2, FCRL3, FCRL4, FCRL5) have tyrosine-based immunoregulatory potential and are expressed by B-lineage subpopulations. FCRL1 may function as an activating coreceptor in B cells. It may also function in B cells activation and differentiation.

Product Categories/Family for FCRL1 recombinant protein

ITIM/ITAM Immunoreceptors and Related Molecules Fc Receptors

References

Du X. et al., 2008, Blood. 111 (1): 338-43. Kazemi T. et al., 2008, Int J Cancer. 123 (9): 2113-9. Baranov K. et al., 2008, J Immunol Methods. 332 (1-2): 73-81.

NCBI and Uniprot Product Information

• NCBI GI #: 16418419
• NCBI GeneID: 115350
• NCBI Accession #: NP_443170.1; NP_001152869.1; NP_001152870.1
• NCBI GenBank Nucleotide #: NM_052938.4
• Molecular Weight: 22,068 Da
• NCBI Official Full Name: Fc receptor-like protein 1 isoform 1
• NCBI Official Synonym Full Names: Fc receptor like 1
• NCBI Official Symbol: FCRL1
• NCBI Official Synonym Symbols: FCRH1; IFGP1; IRTA5; CD307a
• NCBI Protein Information: Fc receptor-like protein 1
• Protein Family: Fc receptor-like protein

NCBI Description

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]