Donkey Ficolin 3 ELISA Kit | FCN3 elisa kit

Donkey Ficolin 3 ELISA Kit

• Gene Names: FCN3; FCNH; HAKA1
• Reactivity: Donkey
• Synonyms: Ficolin 3; Donkey Ficolin 3 ELISA Kit; FCN3 elisa kit

• Reactivity: Donkey
• Sequence Length: 299

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 27754776
• NCBI GeneID: 8547
• NCBI Accession #: NP_003656.2
• NCBI GenBank Nucleotide #: NM_003665.2
• UniProt Accession #: O75636; Q6IBJ5; Q8WW86
• Molecular Weight: 32,903 Da
• NCBI Official Full Name: ficolin-3 isoform 1
• NCBI Official Synonym Full Names: ficolin (collagen/fibrinogen domain containing) 3
• NCBI Official Symbol: FCN3
• NCBI Official Synonym Symbols: FCNH; HAKA1
• NCBI Protein Information: ficolin-3; H-ficolin; ficolin 3; collagen/fibrinogen domain-containing protein 3; collagen/fibrinogen domain-containing lectin 3 p35; ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)
• UniProt Protein Name: Ficolin-3
• Protein Family: Ficolin
• UniProt Gene Name: FCN3
• UniProt Synonym Gene Names: FCNH; HAKA1
• UniProt Entry Name: FCN3_HUMAN

NCBI Description

Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

FCN3: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota. Defects in FCN3 are the cause of ficolin 3 deficiency (FCN3D). FCN3D is a disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine. Belongs to the ficolin lectin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: collagen; extracellular region

Molecular Function: protein binding; carbohydrate binding; antigen binding

Biological Process: negative regulation of virion penetration into host cell; innate immune response; complement activation, lectin pathway; defense response to virus; recognition of apoptotic cell; complement activation

Disease: Immunodeficiency Due To Ficolin 3 Deficiency