SDS-PAGE
CD64 / FCGR1 recombinant protein
Recombinant Mouse CD64 / FCGR1 Protein (His tag)
Gene Names
Fcgr1; CD64; IGGHAFC; AI323638; AV092959; FcgammaRI
Purity
> 97 % as determined by SDS-PAGE
Synonyms
CD64 / FCGR1; Recombinant Mouse CD64 / FCGR1 Protein (His tag); Fcgr1; AI323638; AV092959; CD64; FcgammaRI; IGGHAFC; CD64 / FCGR1 recombinant protein
Host
Human Cells
Purity/Purification
> 97 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
404
Application Notes
The recombinant mouse FCGR1 consists of 284 amino acids after removal of the signal peptide and has a predicted molecular mass of 32 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm FCGR1 is approximately 45-50 kDa due to glycosylation.
Predicted N Terminal
Glu 25
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for CD64 / FCGR1 recombinant protein
Background: Mouse high affinity immunoglobulin gamma Fc receptor I, also known as FCGR1 and CD64, is an integral membrane glycoprotein and a member of the immunoglobulin superfamily. CD64 is a high affinity receptor for the Fc region of IgG gamma and functions in both innate and adaptive immune responses. Receptors that recognize the Fc portion of IgG function in the regulation of immune response and are divided into three classes designated CD64, CD32, and CD16. CD64 is structurally composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNgamma and G-CSF can induce CD64 expression on these cells. The inactivation of the mouse CD64 resulted in a wide range of defects in antibody Fc-dependent functions. Mouse CD64 is an early participant in Fc-dependent cell activation and in the development of immune responses.
Description: A DNA sequence encoding the extracellular domain (Met 1-Pro 297) of mouse FCGR1 (NP_034316.1) precursor was fused with a polyhistidine tag at the C-terminus.
Description: A DNA sequence encoding the extracellular domain (Met 1-Pro 297) of mouse FCGR1 (NP_034316.1) precursor was fused with a polyhistidine tag at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
44,888 Da
NCBI Official Full Name
high affinity immunoglobulin gamma Fc receptor I
NCBI Official Synonym Full Names
Fc receptor, IgG, high affinity I
NCBI Official Symbol
Fcgr1
NCBI Official Synonym Symbols
CD64; IGGHAFC; AI323638; AV092959; FcgammaRI
NCBI Protein Information
high affinity immunoglobulin gamma Fc receptor I
UniProt Protein Name
High affinity immunoglobulin gamma Fc receptor I
UniProt Gene Name
Fcgr1
UniProt Synonym Gene Names
Fcg1; IgG Fc receptor I; FcRI
Uniprot Description
FCGR1A: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Belongs to the immunoglobulin superfamily. FCGR1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 3 F2.1|3 41.72 cM
Cellular Component: external side of plasma membrane; lipid raft; plasma membrane
Molecular Function: IgG binding; IgG receptor activity; leukotriene receptor binding
Biological Process: antibody-dependent cellular cytotoxicity; antigen processing and presentation of exogenous antigen; antigen processing and presentation of exogenous peptide antigen via MHC class I; cell surface receptor linked signal transduction; defense response to bacterium; phagocytosis, engulfment; phagocytosis, recognition; positive regulation of phagocytosis; positive regulation of phagocytosis, engulfment; positive regulation of type IIa hypersensitivity; positive regulation of type III hypersensitivity; receptor-mediated endocytosis; regulation of immune response; response to bacterium
Research Articles on CD64 / FCGR1
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Product Notes
The CD64 / FCGR1 fcgr1 (Catalog #AAA2547229) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant mouse FCGR1 consists of 284 amino acids after removal of the signal peptide and has a predicted molecular mass of 32 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm FCGR1 is approximately 45-50 kDa due to glycosylation. Researchers should empirically determine the suitability of the CD64 / FCGR1 fcgr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD64 / FCGR1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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