Mouse Fibulin-5 ELISA Kit | Fbln5 elisa kit

Mouse Fibulin-5 ELISA Kit

Cat. Num. AAA2884900

• Gene Names: Fbln5; A55; EVEC; DANCE
• Reactivity: Mouse
• Synonyms: Fibulin-5; Mouse Fibulin-5 ELISA Kit; FIBL-5; Developmental arteries and neural crest EGF-like protein; Dance; Fbln5; Fbln5 elisa kit

• Reactivity: Mouse
• Sequence Length: 448

• Assay Type: Sandwich
• Detection Range: 31.2-2000 pg/mL
• Sensitivity: 15.61 pg/mL
• Intra-Assay CV: <=6.3%
• Inter-Assay CV: <=8.2%
• Recovery: 102%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 6753824
• NCBI GeneID: 23876
• NCBI Accession #: NP_035942.1
• NCBI GenBank Nucleotide #: NM_011812.4
• UniProt Accession #: Q9WVH9; Q541Z7
• Molecular Weight: 50,193 Da
• NCBI Official Full Name: fibulin-5
• NCBI Official Synonym Full Names: fibulin 5
• NCBI Official Symbol: Fbln5
• NCBI Official Synonym Symbols: A55; EVEC; DANCE
• NCBI Protein Information: fibulin-5
• UniProt Protein Name: Fibulin-5
• Protein Family: Fibulin
• UniProt Gene Name: Fbln5
• UniProt Synonym Gene Names: Dance; FIBL-5; Dance
• UniProt Entry Name: FBLN5_MOUSE

Uniprot Description

FBLN5: Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling. Defects in FBLN5 are the cause of cutis laxa, autosomal dominant, type 2 (ADCL2). A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. Additional variable clinical features are gastrointestinal diverticula, hernia, and genital prolapse. Rare manifestations are pulmonary artery stenosis, aortic aneurysm, bronchiectasis, and emphysema. Defects in FBLN5 are a cause of cutis laxa, autosomal recessive, type 1A (ARCL1A). A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. The clinical spectrum of autosomal recessive cutis laxa is highly heterogeneous with respect to organ involvement and severity. Type I autosomal recessive cutis laxa is a specific, life-threatening disorder with organ involvement, lung atelectasis and emphysema, diverticula of the gastrointestinal and genitourinary systems, and vascular anomalies. Associated cranial anomalies, late closure of the fontanel, joint laxity, hip dislocation, and inguinal hernia have been observed but are uncommon. Defects in FBLN5 are the cause of age-related macular degeneration type 3 (ARMD3). ARMD is a multifactorial disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the fibulin family.

Protein type: Secreted, signal peptide; Secreted

Cellular Component: extracellular matrix; extracellular region; extracellular space; proteinaceous extracellular matrix

Molecular Function: calcium ion binding; integrin binding; protein C-terminus binding; protein homodimerization activity

Biological Process: cell adhesion; elastic fiber assembly; extracellular matrix organization and biogenesis; secretion