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FAM3B recombinant protein
Recombinant Human FAM3B (C-Fc)
Gene Names
FAM3B; 2-21; ORF9; PANDER; PRED44; C21orf11; C21orf76
Purity
>95% as determined by reducing SDS-PAGE
Synonyms
FAM3B; Recombinant Human FAM3B (C-Fc); Sialic acid-binding Ig-like lectin 9; Siglec-9; CDw329; Protein FOAP-9; SIGLEC9; FAM3B recombinant protein
Host
Human Cells
Purity/Purification
>95% as determined by reducing SDS-PAGE
Form/Format
Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
Sequence
Glu30-Ser235
Species
Human
Tag
C-Fc
Endotoxin
<1.0EU per ug as determined by the LAL method.
Protein Construction
Recombinant Human Protein FAM3B is produced by our Mammalian expression system and the target gene encoding Glu30-Ser235 is expressed with a Fc tag at the C-terminus.
Preparation and Storage
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
This product is provided as lyophilized powder which is shipped with ice packs.
This product is provided as lyophilized powder which is shipped with ice packs.
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SDS-Page
Related Product Information for FAM3B recombinant protein
FAM3B, also known as Pancreatic-derived factor (PANDER), is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. FAM3B can induce apoptosis of alpha and beta cells in a dose- and time-dependent manner. Previous studies showed that FAM3B regulates glucose and lipid metabolism through interaction with liver and endocrine pancreas. FAM3B silencing activates both extrinsic and intrinsic apoptotic pathways. In general, silencing FAM3B promoted p53 phosphorylation and induced p53 accumulation by decreasing Mdm2 expression, which resulted in apoptotic cell death.
Product Categories/Family for FAM3B recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
25,982 Da
NCBI Official Full Name
protein FAM3B isoform b
NCBI Official Synonym Full Names
family with sequence similarity 3, member B
NCBI Official Symbol
FAM3B
NCBI Official Synonym Symbols
2-21; ORF9; PANDER; PRED44; C21orf11; C21orf76
NCBI Protein Information
protein FAM3B; D21M16SJHU19e; pancreatic derived factor; pancreatic-derived factor; cytokine-like protein 2-21
UniProt Protein Name
Protein FAM3B
Protein Family
UniProt Gene Name
FAM3B
UniProt Synonym Gene Names
C21orf11; C21orf76; PANDER
UniProt Entry Name
FAM3B_HUMAN
Uniprot Description
FAM3B: Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. Present in insulin secretory granules and likely cosecreted with insulin. Belongs to the FAM3 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Nuclear envelope; Secreted, signal peptide; Apoptosis; Cytokine
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: extracellular space; extracellular region
Molecular Function: cytokine activity
Biological Process: insulin secretion; apoptosis
Research Articles on FAM3B
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Product Notes
The FAM3B fam3b (Catalog #AAA2569031) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Glu30-Ser2 35. It is sometimes possible for the material contained within the vial of "FAM3B, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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