Extracellular serine/threonine protein kinase FAM20C (FAM20C) Recombinant Protein | FAM20C recombinant protein

Recombinant Human Extracellular serine/threonine protein kinase FAM20C (FAM20C)

Cat. Num. AAA1372422

• Gene Names: FAM20C; RNS; DMP4; G-CK; DMP-4; GEF-CK
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Extracellular serine/threonine protein kinase FAM20C (FAM20C); Recombinant Human Extracellular serine/threonine protein kinase FAM20C (FAM20C); FAM20C recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 93-584aa; Full Length of Mature Protein
• Sequence: DFSSDPSSNLSSHSLEKLPPAAEPAERALRGRDPGALRPHDPAHRPLLRDPGPRRSESPPGPGGDASLLARLFEHPLYRVAVPPLTEEDVLFNVNSDTRLSPKAAENPDWPHAGAEGAEFLSPGEAAVDSYPNWLKFHIGINRYELYSRHNPAIEALLHDLSSQRITSVAMKSGGTQLKLIMTFQNYGQALFKPMKQTREQETPPDFFYFSDYERHNAEIAAFHLDRILDFRRVPPVAGRMVNMTKEIRDVTRDKKLWRTFFISPANNICFYGECSYYCSTEHALCGKPDQIEGSLAAFLPDLSLAKRKTWRNPWRRSYHKRKKAEWEVDPDYCEEVKQTPPYDSSHRILDVMDMTIFDFLMGNMDRHHYETFEKFGNETFIIHLDNGRGFGKYSHDELSILVPLQQCCRIRKSTYLRLQLLAKEEYKLSLLMAESLRGDQVAPVLYQPHLEALDRRLRVVLKAVRDCVERNGLHSVVDDDLDTEHRAASAR
• Sequence Length: 584

• Species: Homo sapiens (Human)
• Production Note: Special Offer: The Mammalian-Cell host-expressed protein is manufactured from a stock plasmid containing the protein gene. Mammalian-Cellhost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The Mammalian-Cell host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select Mammalian-Cell host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to [email protected] for more details.
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 116174742
• NCBI GeneID: 56975
• NCBI Accession #: NP_064608.2
• NCBI GenBank Nucleotide #: NM_020223.3
• UniProt Accession #: Q8IXL6; Q5I0W9; Q7Z4I0; Q9NPT2; A4D2Q5; L8B5W8
• Molecular Weight: 60.4 kDa
• NCBI Official Full Name: extracellular serine/threonine protein kinase FAM20C
• NCBI Official Synonym Full Names: FAM20C, golgi associated secretory pathway kinase
• NCBI Official Symbol: FAM20C
• NCBI Official Synonym Symbols: RNS; DMP4; G-CK; DMP-4; GEF-CK
• NCBI Protein Information: extracellular serine/threonine protein kinase FAM20C
• UniProt Protein Name: Extracellular serine/threonine protein kinase FAM20C
• Protein Family: Extracellular serine/threonine protein kinase
• UniProt Gene Name: FAM20C
• UniProt Synonym Gene Names: GEF-CK

NCBI Description

This gene encodes a member of the family of secreted protein kinases. The encoded protein binds calcium and phosphorylates proteins involved in bone mineralization. Mutations in this gene are associated with the autosomal recessive disorder Raine syndrome. [provided by RefSeq, Apr 2014]

Uniprot Description

Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (PubMed:26091039). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (PubMed:26091039). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:22582013, PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (PubMed:26091039).