FCMR/FAIM3 Recombinant Protein | FCMR recombinant protein

FCMR/FAIM3 Protein, Human, Recombinant (hFc Tag)

Cat. Num. AAA8121465

• Gene Names: FAIM3; FCMR; TOSO
• Purity: >65% as determined by SDS-PAGE
• Synonyms: FCMR/FAIM3; FCMR/FAIM3 Protein; Human; Recombinant (hFc Tag); Human FAIM3 Protein (Fc Tag); FCMR Protein; TOSO Protein; Fc fragment of IgM receptor; FCMR recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >65% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Gly251

• Species: Human
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Arg 18
• Tag: C-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the human FAIM3 (NP_005440.1)(Met1-Gly251) was expressed with the Fc region of human IgG1 at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 4885641
• NCBI GeneID: 9214
• NCBI Accession #: NP_005440.1
• NCBI GenBank Nucleotide #: NM_005449.4
• UniProt Accession #: O60667; A8K7J2; B7Z6Z0; D9MWM3
• Molecular Weight: 33,828 Da
• NCBI Official Full Name: fas apoptotic inhibitory molecule 3 isoform a
• NCBI Official Synonym Full Names: Fas apoptotic inhibitory molecule 3
• NCBI Official Symbol: FAIM3
• NCBI Official Synonym Symbols: FCMR; TOSO
• NCBI Protein Information: fas apoptotic inhibitory molecule 3; Fc mu receptor; IgM Fc receptor; immunoglobulin mu Fc receptor; regulator of Fas-induced apoptosis Toso
• UniProt Protein Name: Fas apoptotic inhibitory molecule 3
• Protein Family: Fas apoptotic inhibitory molecule
• UniProt Gene Name: FAIM3
• UniProt Synonym Gene Names: TOSO
• UniProt Entry Name: FAIM3_HUMAN

NCBI Description

Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]

Uniprot Description

FAIM3: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: extracellular region; integral to membrane

Biological Process: immune system process; cellular defense response; negative regulation of apoptosis