Rabbit anti-Mouse, Rat HES1 Polyclonal Antibody | anti-HES1 antibody

HES1 Polyclonal Antibody

Cat. Num. AAA2556273

• Gene Names: Hes1; Hry; bHLHb39
• Reactivity: Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purification
• Synonyms: HES1; Polyclonal Antibody; HES1 Polyclonal Antibody; bHLHb39; C-HAIRY1; c-hairy1A; Class B basic helix-loop-helix protein 39; FLJ20408; Hairy and enhancer of split 1 (Drosophila); Hairy and enhancer of split 1; Hairy homolog (Drosophila); Hairy homolog; Hairy like; Hairy-like protein; HAIRY1; HES-1; hes1; Hes1 hairy and enhancer of split 1 (Drosophila); HHL; HL; HRY; MGC129109; OTTHUMP00000209031; RHL; Transcription factor HES-1; anti-HES1 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 100 mug/ml BSA and 50% glycerol.
• Concentration: 410 mug/mL (varies by lot)
• Sequence Length: 282

• Applicable Applications for anti-HES1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: KLH conjugated synthetic peptide corresponding to Mouse HES1
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western Blot analysis of various samples using HES1 Polyclonal Antibody at dilution of 1:600.)

Related Product Information for anti-HES1 antibody

This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.

Product Categories/Family for anti-HES1 antibody

Neuroscience; Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 6680205
• NCBI GeneID: 15205
• NCBI Accession #: NP_032261.1
• NCBI GenBank Nucleotide #: NM_008235.2
• UniProt Accession #: P35428
• Molecular Weight: Calculated: 30kDa; Observed: 30kDa
• NCBI Official Full Name: transcription factor HES-1
• NCBI Official Synonym Full Names: hes family bHLH transcription factor 1
• NCBI Official Symbol: Hes1
• NCBI Official Synonym Symbols: Hry; bHLHb39
• NCBI Protein Information: transcription factor HES-1
• UniProt Protein Name: Transcription factor HES-1
• Protein Family: Protein
• UniProt Gene Name: Hes1
• UniProt Synonym Gene Names: Hes-1

Uniprot Description

Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage ().