FABP6/I-BABP recombinant protein

Recombinant Human FABP6/I-BABP Protein (N-His)

Cat. Num. AAA2557290

• Gene Names: FABP6; ILBP; I-15P; I-BAP; ILBP3; ILLBP; I-BABP; I-BALB
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: FABP6/I-BABP; Recombinant Human FABP6/I-BABP Protein (N-His); Gastrotropin; GT; Fatty Acid-Binding Protein 6; Ileal Lipid-Binding Protein; ILBP; Intestinal 15 kDa Protein; I-15P; Intestinal Bile Acid-Binding Protein; I-BABP; FABP6; ILLBP; FABP6/I-BABP recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Supplied as a 0.2 mum filtered solution of 20mM TrisHCl, 0.5mM DTT, 50% Glycerol, pH 8.0.
• Sequence: Met1-Ala128
• Sequence Length: 19

• Species: Human
• Endotoxin: < 1.0 EU per mug as determined by the LAL method.
• Fusion Tag: N-His
• Preparation and Storage: Store at < -20 degree C, stable for 6 months. Please minimize freeze-thaw cycles.

Related Product Information for FABP6/I-BABP recombinant protein

Protein Construction: Recombinant Human FABP6 is produced by our E Coli expression system and the target gene encoding Met1-Ala128 is expressed with a 6His tag at the N-terminus.

Background: Fatty Acid-Binding Protein 6 (FABP6) is cytoplasmic protein that binds long-chain fatty acids and other hydrophobic ligands which belongs to the calycin superfamily. FABP6 expression is restricted in the small intestine to the ileum where it is involved in the enterohepatic circulation of bile acids. FABP6 forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior. Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. FABP6 plays a role in fatty acid uptake, transport, and metabolism. FABP6 stimulates gastric acid and pepsinogen secretion. It seems to be able to bind to bile salts and bilirubins.

NCBI and Uniprot Product Information

• NCBI GI #: 6691917
• NCBI GeneID: 2172
• UniProt Accession #: P51161
• Molecular Weight: Molecular Mass: 16.6kDa; Actual Protein Molecular Mass: 15kDa
• NCBI Official Full Name: FABP6, partial
• NCBI Official Synonym Full Names: fatty acid binding protein 6
• NCBI Official Symbol: FABP6
• NCBI Official Synonym Symbols: ILBP; I-15P; I-BAP; ILBP3; ILLBP; I-BABP; I-BALB
• NCBI Protein Information: gastrotropin
• UniProt Protein Name: Gastrotropin
• UniProt Gene Name: FABP6
• UniProt Synonym Gene Names: ILBP; ILLBP; GT; ILBP; I-15P; I-BABP
• UniProt Entry Name: FABP6_HUMAN

NCBI Description

This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

FABP6: Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. 2 isoforms of the human protein are produced by alternative promoter.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 5q33.3-q34

Cellular Component: cytoplasm; cytosol

Molecular Function: transporter activity; lipid binding

Biological Process: bile acid and bile salt transport; negative regulation of cell proliferation; bile acid metabolic process; lipid metabolic process; transmembrane transport