Coagulation Factor X/F10 Recombinant Protein | F10 recombinant protein

Recombinant Mouse Coagulation Factor X/F10 Protein (C-6His)

Cat. Num. AAA2553465

• Gene Names: F10; fX; Cf10
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Coagulation Factor X/F10; Recombinant Mouse Coagulation Factor X/F10 Protein (C-6His); F10; Coagulation factor X; Stuart factor; F10 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM MES, 150mM NaCl and 1mM CaCl2 pH 7.5.
• Sequence Positions: Gly21-Asn481
• Sequence Length: 481

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for F10 recombinant protein

Mouse coagulation factor X/F10 a member of the peptidase S1 family. The mature F10 is composed mostly of two EGF-like domains, one Gla gamma-carboxy-glutamate domain and one peptidase S1 domain. Factor Xa is a vitamin K-dependent plasma protease that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. The two chains of F10 are formed from a single-chain precursor by the excision of two Arg residues. A single-chain precursor is initially synthesized in the liver. The light and heavy chains are linked together by disulfide bonds. The light chain contains a Gla and two EGF-like domains. The heavy chain corresponds to the serine protease domain. It can form a heterodimer with SERPINA5.

NCBI and Uniprot Product Information

• NCBI GI #: 110625994
• NCBI GeneID: 14058
• NCBI Accession #: NP_031998.3
• NCBI GenBank Nucleotide #: NM_007972.4
• UniProt Accession #: O88947; O54740; Q99L32
• Molecular Weight: Molecular Mass: 55.1 kDa; Actual Protein Molecular Mass: 55kDa
• NCBI Official Full Name: coagulation factor X isoform 2 preproprotein
• NCBI Official Synonym Full Names: coagulation factor X
• NCBI Official Symbol: F10
• NCBI Official Synonym Symbols: fX; Cf10
• NCBI Protein Information: coagulation factor X
• UniProt Protein Name: Coagulation factor X
• Protein Family: Coagulation factor
• UniProt Gene Name: F10

NCBI Description

This gene encodes factor X, a component of both the intrinsic and extrinsic blood coagulation pathways. The encoded protein is a zymogen that undergoes further processing in a vitamin K-dependent manner to generate mature factor X, a heterodimer comprised of disulfide-linked heavy and light chains. The mature factor X is proteolytically activated either by factor IXa (intrinsic pathway) or factor VIIa (extrinsic pathway) to form factor Xa serine endopeptidase. Activated factor Xa catalyzes the conversion of prothrombin to thrombin. A complete lack of the encoded protein is fatal to mice. A severe deficiency of the encoded protein in mice causes age-dependent iron deposition and cardiac fibrosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

Uniprot Description

Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.