Human exosome component 1 ELISA Kit | EXOSC1 elisa kit
Human Exosome complex component CSL4, EXOSC1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. [provided by RefSeq, Jul 2008]
Uniprot Description
EXOSC1: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.
Protein type: Nucleolus; EC 3.1.13.-; Ribonuclease; RNA-binding
Chromosomal Location of Human Ortholog: 10q24
Cellular Component: nucleoplasm; cytoplasm; nucleolus; exosome (RNase complex); nucleus; cytosol; nuclear exosome (RNase complex)
Molecular Function: protein binding; exoribonuclease activity; RNA binding
Biological Process: gene expression; rRNA processing; mRNA catabolic process, deadenylation-dependent decay
Research Articles on EXOSC1
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Product Notes
The Human EXOSC1 exosc1 (Catalog #AAA9317696) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9317696 ELISA Kit recognizes Human EXOSC1. It is sometimes possible for the material contained within the vial of "exosome component 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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