Goat anti-Human APOH / Apolipoprotein H Polyclonal Antibody | anti-APOH antibody

Goat Polyclonal (IgG) to Human APOH / Apolipoprotein H

Cat. Num. AAA242583

• Gene Names: APOH; BG; B2G1; B2GP1
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: APOH / Apolipoprotein H; Polyclonal Antibody; Goat Polyclonal (IgG) to Human APOH / Apolipoprotein H; Anti-APOH / Apolipoprotein H Antibody IHC-plus; APOH; Apo-H; Anticardiolipin cofactor; Apolipoprotein H; B2GP1; B2GPI; Beta-2-glycoprotein I; APC inhibitor; Beta(2)GPI; BG; B2G1; Beta-2-glycoprotein 1; Human APOH; anti-APOH antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human beta2GP-I. A single precipitin arc is observed with normal plasma. No arc was seen with beta2GP-I deficient plasma.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: 10 mM HEPES, pH 7.4, 0.15 M sodium chloride, 50% glycerol.
• Concentration: 2 mg/ml (varies by lot)
• Sequence Length: 345

• Applicable Applications for anti-APOH antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA), Immunoelectrophoresis
• Application Notes: ELISA, IE, IHC-P (2.5 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Human beta2-Glycoprotein-I (beta2GP-I) purified from plasma.
• Immunogen Type: Purified protein
• Immunogen: APOH / Apolipoprotein H antibody was raised against human beta2-Glycoprotein-I (beta2GP-I) purified from plasma.
• Preparation and Storage: Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

Immunohistochemistry (IHC)

(Anti-APOH / Apolipoprotein H antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Related Product Information for anti-APOH antibody

Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections.

NCBI and Uniprot Product Information

• NCBI GI #: 153266841
• NCBI GeneID: 350
• NCBI Accession #: NP_000033.2
• NCBI GenBank Nucleotide #: NM_000042.2
• UniProt Accession #: P02749; Q9UCN7; B2R9M3
• Molecular Weight: 38,298 Da
• NCBI Official Full Name: beta-2-glycoprotein 1
• NCBI Official Synonym Full Names: apolipoprotein H (beta-2-glycoprotein I)
• NCBI Official Symbol: APOH
• NCBI Official Synonym Symbols: BG; B2G1; B2GP1
• NCBI Protein Information: beta-2-glycoprotein 1; B2GPI; apo-H; beta(2)GPI; APC inhibitor; anticardiolipin cofactor; activated protein C-binding protein
• UniProt Protein Name: Beta-2-glycoprotein 1
• Protein Family: Beta-2-glycoprotein
• UniProt Gene Name: APOH
• UniProt Synonym Gene Names: B2G1; Apo-H; B2GPI; Beta(2)GPI
• UniProt Entry Name: APOH_HUMAN

NCBI Description

Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]

Uniprot Description

APOH: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

Protein type: Secreted, signal peptide; Lipid-binding; Secreted

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: extracellular matrix; extracellular space; chylomicron; cell surface

Molecular Function: heparin binding; identical protein binding; protein binding; phospholipid binding; glycoprotein binding; lipid binding

Biological Process: negative regulation of myeloid cell apoptosis; negative regulation of angiogenesis; negative regulation of fibrinolysis; positive regulation of blood coagulation; triacylglycerol metabolic process; negative regulation of endothelial cell proliferation; negative regulation of blood coagulation; positive regulation of lipoprotein lipase activity; triacylglycerol transport; blood coagulation, intrinsic pathway; plasminogen activation; regulation of fibrinolysis