ER Resident Protein 44/ERp44/TXNDC4 Recombinant Protein | ERp44/TXNDC4 recombinant protein

Recombinant Human ER Resident Protein 44/ERp44/TXNDC4 Protein (C-6His)

Cat. Num. AAA2552636

• Gene Names: ERP44; PDIA10; TXNDC4
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: ER Resident Protein 44/ERp44/TXNDC4; Recombinant Human ER Resident Protein 44/ERp44/TXNDC4 Protein (C-6His); Thioredoxin domain-containing protein 4; ER protein 44; KIAA0573; TXNDC4; ERp44/TXNDC4 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Supplied as a 0.2 mum filtered solution of 20mM Tris HCl, 10% Glycerol, pH 7.5.
• Sequence Positions: Glu30-Asp402
• Sequence Length: 406

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Store at < -20 degree C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.

Related Product Information for ERp44/TXNDC4 recombinant protein

Endoplasmic reticulum resident protein 44 (TXNDC4) is is a 406 amino acid protein that contains one thioredoxin domain. TXNDC4 mediates thiol-dependent retention in the early secretory pathway and forms mixed disulfides with substrate proteins through its conserved CRFS motif.It can inhibit the calcium channel activity of ITPR1.It may have a role in the control of oxidative protein folding in the endoplasmic reticulum.

NCBI and Uniprot Product Information

• NCBI GI #: 52487191
• NCBI GeneID: 23071
• NCBI Accession #: NP_055866.1
• NCBI GenBank Nucleotide #: NM_015051.2
• UniProt Accession #: Q9BS26; O60319; Q4VXC1; Q5VWZ7; Q6UW14; Q8WX67
• Molecular Weight: Molecular Mass: 44.2 kDa; Actual Protein Molecular Mass: 50 kDa
• NCBI Official Full Name: endoplasmic reticulum resident protein 44
• NCBI Official Synonym Full Names: endoplasmic reticulum protein 44
• NCBI Official Symbol: ERP44
• NCBI Official Synonym Symbols: PDIA10; TXNDC4
• NCBI Protein Information: endoplasmic reticulum resident protein 44
• UniProt Protein Name: Endoplasmic reticulum resident protein 44
• UniProt Gene Name: ERP44
• UniProt Synonym Gene Names: KIAA0573; TXNDC4; ER protein 44; ERp44

NCBI Description

This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-retention sequence. This protein functions as a pH-regulated chaperone of the secretory pathway and likely plays a role in protein quality control at the endoplasmic reticulum - Golgi interface. [provided by RefSeq, Dec 2016]

Uniprot Description

Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum.