anti-Human IGF2BP2 Antibody | anti-IGF2BP2 antibody

IGF2BP2 Antibody

Cat. Num. AAA853361

• Gene Names: IGF2BP2; IMP2; IMP-2; VICKZ2
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: IGF2BP2; IGF2BP2 Antibody; Insulin-like growth factor 2 mRNA-binding protein 2; IGF2 mRNA-binding protein 2; IGF-II mRNA-binding protein 2; IMP-2; Hepatocellular carcinoma autoantigen p62; VICKZ family member 2; IMP2; VICKZ2; anti-IGF2BP2 antibody

• Reactivity: Human
• Specificity: IGF2BP2 antibody detects endogenous levels of total IGF2BP2 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 556

• Applicable Applications for anti-IGF2BP2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; ELISA: 1:20000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human IGF2BP2.
• Preparation and Storage: Store at-20 degree C for 1 year.

Testing Data #2

(Western blot analysis of extracts from HuvEC and K562 cells, using IGF2BP2 antibody.)

Product Categories/Family for anti-IGF2BP2 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Collins F.S., Submitted (JAN-2008). Gibbs R.A., Nature 440:1194-1198(2006). Kobarg J., Biol. Chem. 384:25-37(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 56118219
• NCBI GeneID: 10644
• NCBI Accession #: NP_001007226.1
• NCBI GenBank Nucleotide #: NM_001007225.2
• UniProt Accession #: Q9Y6M1; A0A4Z0; B3FTN2; B3FTN3; B3FTN4
• Molecular Weight: 58,578 Da
• NCBI Official Full Name: insulin-like growth factor 2 mRNA-binding protein 2 isoform b
• NCBI Official Synonym Full Names: insulin like growth factor 2 mRNA binding protein 2
• NCBI Official Symbol: IGF2BP2
• NCBI Official Synonym Symbols: IMP2; IMP-2; VICKZ2
• NCBI Protein Information: insulin-like growth factor 2 mRNA-binding protein 2
• UniProt Protein Name: Insulin-like growth factor 2 mRNA-binding protein 2
• Protein Family: Insulin-like growth factor 2 mRNA-binding protein
• UniProt Gene Name: IGF2BP2
• UniProt Synonym Gene Names: IMP2; VICKZ2; IGF2 mRNA-binding protein 2; IMP-2

NCBI Description

This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]

Uniprot Description

RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts.