Epididymis protein 4, HE4 Recombinant Protein
Human Epididymis protein 4, HE4 Protein (Active)
Applications
ELISA, SDS-Page
Purity
>95% by SDS-PAGE
Synonyms
Epididymis protein 4; HE4; Human Epididymis protein 4; HE4 Protein (Active); WAP four-disulfide core domain protein 2; WFDC2; HE4 recombinant protein
Host
E. coli
Purity/Purification
>95% by SDS-PAGE
Form/Format
Liquid; Each vial contains Tris-HCL (pH7.4 ± 0.2) with 0.2% sodium azide.
Concentration
1.2 mg/ml (varies by lot)
Applicable Applications for Epididymis protein 4, HE4 recombinant protein
ELISA, SDS-PAGE
Application Notes
Other applications have not been tested. The optimal dilutions should be determined by end user.
Preparation and Storage
Ships on Blue ice.
Upon receipt, aliquot and store at -20°C and -80°C for long term.
Avoid repeated freeze thaw cycles.
Upon receipt, aliquot and store at -20°C and -80°C for long term.
Avoid repeated freeze thaw cycles.
Related Product Information for Epididymis protein 4, HE4 recombinant protein
Description: Recombinant full length human HE4 protein with molecular weight 14 kDa.
Background: WAP four-disulfide core domain protein 2, also known as Human Epididymis Protein 4 (HE4) is a protein that in humans is encoded by the WFDC2 gene. This gene is amplified in ovarian carcinomas, whereas its expression in normal tissues, including ovary, is low. Although the function of the HE4 protein is unknown, it is a member of a family of stable 4-disulfide core proteins that are secreted at high levels. HE4 is a secreted glycoprotein that is overexpressed by serous and endometrioid EOCs (epithelial ovarian carcinomas). Its expression in cortical inclusion cysts suggests that formation of Mullerian epithelium is a prerequisite step in the development of some types of EOCs.
Background: WAP four-disulfide core domain protein 2, also known as Human Epididymis Protein 4 (HE4) is a protein that in humans is encoded by the WFDC2 gene. This gene is amplified in ovarian carcinomas, whereas its expression in normal tissues, including ovary, is low. Although the function of the HE4 protein is unknown, it is a member of a family of stable 4-disulfide core proteins that are secreted at high levels. HE4 is a secreted glycoprotein that is overexpressed by serous and endometrioid EOCs (epithelial ovarian carcinomas). Its expression in cortical inclusion cysts suggests that formation of Mullerian epithelium is a prerequisite step in the development of some types of EOCs.
References
1. Hellström, Ingegerd; John Raycraft, Martha Hayden-Ledbetter, Jeffrey A. Ledbetter, Michèl Schummer, Martin McIntosh, Charles Drescher, Nicole Urban, and Karl Erik Hellström (2003-07-01). "The HE4 (WFDC2) Protein Is a Biomarker for Ovarian Carcinoma". Cancer Research 63 (13): 3695-3700. 2. Drapkin R, von Horsten HH, Lin Y et al. (2005). "Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas". Cancer Res. 65 (6): 2162-9.
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Product Notes
The Epididymis protein 4, HE4 (Catalog #AAA355616) is a Recombinant Protein produced from E. coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Epididymis protein 4, HE4 can be used in a range of immunoassay formats including, but not limited to, ELISA, SDS-PAGE. Other applications have not been tested. The optimal dilutions should be determined by end user. Researchers should empirically determine the suitability of the Epididymis protein 4, HE4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Epididymis protein 4, HE4, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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