Eukaryotic Translation Initiation Factor 4H Recombinant Protein | EIF4H recombinant protein

Recombinant Human Eukaryotic Translation Initiation Factor 4H

Cat. Num. AAA144806

• Gene Names: EIF4H; WSCR1; WBSCR1; eIF-4H
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Eukaryotic Translation Initiation Factor 4H; Recombinant Human Eukaryotic Translation Initiation Factor 4H; EIF4H Human; Eukaryotic Translation Initiation Factor 4H Human Recombinant; Eukaryotic translation initiation factor 4H; eIF-4H; Williams-Beuren syndrome chromosomal region 1 protein; EIF4H; KIAA0038; WBSCR1; WSCR1; EIF4H recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: EIF4H protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol and 2mM DTT.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMADFDT YDDRAYSSFG GGRGSRGSAG GHGSRSQKEL PTEPPYTAYV GNLPFNTVQG DIDAIFKDLS IRSVRLVRDK DTDKFKGFCY VEFDEVDSLK EALTYDGALL GDRSLRVDIA EGRKQDKGGF GFRKGGPDDR GMGSSRESRG GWDSRDDFNS GFRDDFLGGR GGSRPGDRRT GPPMGSRFRD GPPLRGSNMD FREPTEEERA QRPRLQLKPR TVATPLNQVA NPNSAIFGGA RPREEVVQKE QE.
• Sequence Length: 248

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for EIF4H recombinant protein

Description: EIF4H Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 272 amino acids (1-248 a.a) and having a molecular mass of 29.9kDa.EIF4H is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Eukaryotic translation initiation factor 4H (EIF4H) is a 248 amino acid protein which localizes to the perinuclear region of the cytoplasm and is expressed as 2 isoforms, termed short and long. EIF4H functions to stimulate the initiation of protein synthesis at the level of mRNA employment. EIF4H stimulates the RNA-dependent ATP hydrolysis catalyzed by EIF4A and EIF4B. EIF4H gene defects linked to Williams- Beuren syndrome (WBS), a rare developmental disorder characterized by cardiovascular and musculo-skeletal abnormalities and caused by the deletion of contiguous genes at 7q11.23.

Product Categories/Family for EIF4H recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Eukaryotic Translation Initiation Factor

NCBI and Uniprot Product Information

• NCBI GI #: 11559923
• NCBI GeneID: 7458
• NCBI Accession #: NP_071496.1
• NCBI GenBank Nucleotide #: NM_022170.1
• UniProt Accession #: Q15056; A8K3R1; D3DXF6; D3DXF8
• Molecular Weight: 25,200 Da
• NCBI Official Full Name: eukaryotic translation initiation factor 4H isoform 1
• NCBI Official Synonym Full Names: eukaryotic translation initiation factor 4H
• NCBI Official Symbol: EIF4H
• NCBI Official Synonym Symbols: WSCR1; WBSCR1; eIF-4H
• NCBI Protein Information: eukaryotic translation initiation factor 4H; Williams-Beuren syndrome chromosome region 1
• UniProt Protein Name: Eukaryotic translation initiation factor 4H
• Protein Family: Eukaryotic translation initiation factor
• UniProt Gene Name: EIF4H
• UniProt Synonym Gene Names: KIAA0038; WBSCR1; WSCR1; eIF-4H
• UniProt Entry Name: IF4H_HUMAN

NCBI Description

This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Description

EIF4H: eukaryotic translation initiation factor 4H stimulates protein translation. May stimulate the activities of EIF4A, EIF4B and EIF4F during the steps involving mRNA binding and utilization in the initiation of protein biosynthesis. Binds mRNA. Two alternatively spliced isoforms have been described. The short isoform is the predominant isoform and is expressed alone in liver and skeletal muscle. Both isoforms are expressed in fibroblast, spleen, testis and bone marrow. Levels are high in lung and pancreas and low in heart, frontal cortex and kidney.

Protein type: Translation; RNA-binding; Translation initiation

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: membrane; perinuclear region of cytoplasm; eukaryotic translation initiation factor 4F complex; cytosol

Molecular Function: protein binding; translation factor activity, nucleic acid binding; RNA binding; translation initiation factor activity; nucleotide binding

Biological Process: developmental growth; cellular protein metabolic process; translation; viral reproduction; sexual reproduction; translational initiation; gene expression; regulation of translational initiation

Disease: Williams-beuren Syndrome