Mouse eukaryotic translation initiation factor 4 gamma, 2 ELISA Kit | EIF4G2 elisa kit
Mouse Eukaryotic translation initiation factor 4 gamma 2, EIF4G2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G, that contains the binding sites for eIF4A and eIF3; eIF4G in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. Transgene expression of the apolipoprotein B mRNA-editing enzyme (APOBEC-1) causes extensive editing of this mRNA, which could contribute to the potent oncogenesis induced by overexpression of APOBEC-1. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse. Two alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
EIF4G2: a general repressor of translation by forming translationally inactive complexes. Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Interacts with the protein kinases Mnk1 and -2. Binds EIF4A and EIF3. Cleaved by some caspases and viral proteases.
Protein type: Translation initiation; RNA-binding; Translation
Cellular Component: membrane; eukaryotic translation initiation factor 4F complex; cytoplasm
Molecular Function: protein binding; RNA binding; translation factor activity, nucleic acid binding; translation initiation factor activity
Biological Process: regulation of translation; translation; translational initiation; regulation of translational initiation
Research Articles on EIF4G2
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Product Notes
The Mouse EIF4G2 eif4g2 (Catalog #AAA9342243) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9342243 ELISA Kit recognizes Mouse EIF4G2. It is sometimes possible for the material contained within the vial of "eukaryotic translation initiation factor 4 gamma, 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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