Human eukaryotic translation initiation factor 4E binding protein 3 ELISA Kit | EIF4EBP3 elisa kit

Human Eukaryotic translation initiation factor 4E-binding protein 3, EIF4EBP3 ELISA Kit

Cat. Num. AAA9329346

• Gene Names: EIF4EBP3; 4EBP3; 4E-BP3
• Reactivity: Human
• Synonyms: eukaryotic translation initiation factor 4E binding protein 3; Human Eukaryotic translation initiation factor 4E-binding protein 3; EIF4EBP3 ELISA Kit; Human Eukaryotic translation initiation factor 4E-binding protein 3 (EIF4EBP3) ELISA kit; 4E-BP3; eukaryotic initiation factor 4E-binding protein 3; EIF4EBP3 elisa kit

• Reactivity: Human

• Samples: Human Body Fluids And Tissue Homogenates
• Assay Type: Quantitative Sandwich
• Detection Range: 62.5pg/ml-2000pg/ml
• Sensitivity: 10pg/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for EIF4EBP3 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only! This kit is intended to be used for determine the level of EIF4E (hereafter termed "analyte") in undiluted original Human body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 4503537
• NCBI GeneID: 8637
• NCBI Accession #: NP_003723.1
• NCBI GenBank Nucleotide #: NM_003732.2
• UniProt Accession #: O60516
• Molecular Weight: 10,873 Da
• NCBI Official Full Name: eukaryotic translation initiation factor 4E-binding protein 3
• NCBI Official Synonym Full Names: eukaryotic translation initiation factor 4E binding protein 3
• NCBI Official Symbol: EIF4EBP3
• NCBI Official Synonym Symbols: 4EBP3; 4E-BP3
• NCBI Protein Information: eukaryotic translation initiation factor 4E-binding protein 3; eIF4E-binding protein 3; eukaryotic initiation factor 4E-binding protein 3
• UniProt Protein Name: Eukaryotic translation initiation factor 4E-binding protein 3
• Protein Family: Eukaryotic translation initiation factor 4E-binding protein
• UniProt Gene Name: EIF4EBP3
• UniProt Synonym Gene Names: 4E-BP3; eIF4E-binding protein 3
• UniProt Entry Name: 4EBP3_HUMAN

NCBI Description

This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010]

Uniprot Description

4E-BP3: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. EIF4EBP3 interacts with EIF4E. Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus. Belongs to the eIF4E-binding protein family.

Protein type: Translation; Translation initiation

Chromosomal Location of Human Ortholog: 5q31.3

Cellular Component: membrane; eukaryotic translation initiation factor 4F complex

Molecular Function: protein binding; translation repressor activity; eukaryotic initiation factor 4E binding

Biological Process: negative regulation of translational initiation