Eukaryotic Translation Initiation Factor 2B Subunit 1 Alpha Recombinant Protein | EIF2B1 recombinant protein

Recombinant Human Eukaryotic Translation Initiation Factor 2B Subunit 1 Alpha

Cat. Num. AAA144901

• Gene Names: EIF2B1; EIF2B; EIF2BA
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Eukaryotic Translation Initiation Factor 2B Subunit 1 Alpha; Recombinant Human Eukaryotic Translation Initiation Factor 2B Subunit 1 Alpha; EIF2B1 Human; Eukaryotic Translation Initiation Factor 2B Subunit 1 Alpha Human Recombinant; Translation initiation factor eIF-2B subunit alpha; eIF-2B GDP-GTP exchange factor subunit alpha; EIF2B1; EIF2BA; EIF2B; EIF2B1 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: The EIF2B1 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.1M NaCl.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MDDKELIEYF KSQMKEDPDM ASAVAAIRTL LEFLKRDKGE TIQGLRANLT SAIETLCGVD SSVAVSSGGE LFLRFISLAS LEYSDYSKCK KIMIERGELF LRRISLSRNK IADLCHTFIK DGATILTHAY SRVVLRVLEA AVAAKKRFSV YVTESQPDLS GKKMAKALCH LNVPVTVVLD AAVGYIMEKA DLVIVGAEGV VENGGIINKI GTNQMAVCAK AQNKPFYVVA ESFKFVRLFP LNQQDVPDKF KYKADTLKVA QTGQDLKEEH PWVDYTAPSL ITLLFTDLGV LTPSAVSDEL IKLYL.
• Sequence Length: 305

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for EIF2B1 recombinant protein

Introduction: EIF2B1 is one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), which is a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Phosphorylation of eIF2 inhibits GEF activity of EIF2B, an inhibition which requires the eIF2B1 subunit. Defects in eIF2B1 are a cause of leukoencephalopathy with vanishing white matter (VWM), a brain disease which is characterized by head trauma and motor deterioration.

Product Categories/Family for EIF2B1 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Eukaryotic Translation Initiation Factor

NCBI and Uniprot Product Information

• NCBI GI #: 4503503
• NCBI GeneID: 1967
• NCBI Accession #: NP_001405.1
• NCBI GenBank Nucleotide #: NM_001414.3
• UniProt Accession #: Q14232; Q3SXP4; A6NLY9; B4DGX0
• Molecular Weight: 24,618 Da
• NCBI Official Full Name: translation initiation factor eIF-2B subunit alpha
• NCBI Official Synonym Full Names: eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
• NCBI Official Symbol: EIF2B1
• NCBI Official Synonym Symbols: EIF2B; EIF2BA
• NCBI Protein Information: translation initiation factor eIF-2B subunit alpha; eIF-2B GDP-GTP exchange factor subunit alpha
• UniProt Protein Name: Translation initiation factor eIF-2B subunit alpha
• Protein Family: Translation initiation factor
• UniProt Gene Name: EIF2B1
• UniProt Synonym Gene Names: EIF2BA
• UniProt Entry Name: EI2BA_HUMAN

NCBI Description

This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Oct 2009]

Uniprot Description

eIF2B-alpha: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Defects in EIF2B1 are a cause of leukodystrophy with vanishing white matter (VWM). VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy. Belongs to the eIF-2B alpha/beta/delta subunits family.

Protein type: Translation initiation; Translation

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: eukaryotic translation initiation factor 2B complex; membrane; cytoplasm; plasma membrane; cytosol

Molecular Function: protein binding; GDP binding; GTP binding; translation initiation factor activity; guanyl-nucleotide exchange factor activity; S-methyl-5-thioribose-1-phosphate isomerase activity; enzyme regulator activity

Biological Process: response to peptide hormone stimulus; translation; cellular response to stimulus; cellular protein metabolic process; methionine salvage; response to heat; translational initiation; response to glucose stimulus; negative regulation of translation initiation in response to stress; gene expression; oligodendrocyte development; regulation of translational initiation; positive regulation of GTPase activity

Disease: Leukoencephalopathy With Vanishing White Matter