EDAR recombinant protein

EDAR, 27-448aa, Human, His tag, E Coli (Denatured)

Cat. Num. AAA205783

• Gene Names: EDAR; DL; ED3; ED5; ED1R; EDA3; HRM1; EDA1R; ECTD10A; ECTD10B; EDA-A1R
• Applications: SDS-Page
• Purity: > 85% by SDS-PAGE
• Synonyms: EDAR; 27-448aa; Human; His tag; E Coli (Denatured); Tumor necrosis factor receptor superfamily member EDAR; DL; ECTD10A; ECTD10B; ED1R; ED3; ED5; EDA-A1R; EDA1R; EDA3; HRM1; EDAR recombinant protein

• Host: E Coli
• Purity/Purification: > 85% by SDS-PAGE
• Form/Format: Liquid. In 20mM Tris-HCl (pH 8.0) containing 10% glycerol
• Concentration: 0.25 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSEYSNCGE NEYYNQTTGL CQECPPCGPG EEPYLSCGYG TKDEDYGCVP CPAEKFSKGG YQICRRHKDC EGFFRATVLT PGDMENDAEC GPCLPGYYML ENRPRNIYGM VCYSCLLAPP NTKECVGATS GASANFPGTS GSSTLSPFQH AHKELSGQGH LATALIIAMS TIFIMAIAIV LIIMFYILKT KPSAPACCTS HPGKSVEAQV SKDEEKKEAP DNVVMFSEKD EFEKLTATPA KPTKSENDAS SENEQLLSRS VDSDEEPAPD KQGSPELCLL SLVHLAREKS ATSNKSAGIQ SRRKKILDVY ANVCGVVEGL SPTELPFDCL EKTSRMLSST YNSEKAVVKT WRHLAESFGL KRDEIGGMTD GMQLFDRIST AGYSIPELLT KLVQIERLDA VESLCADILE WAGVVPPASQ PHAAS
• Sequence Length: 448

• Applicable Applications for EDAR recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for EDAR recombinant protein

EDAR is a member of the tumor necrosis factor receptor family. This protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia. Recombinant human EDAR protein, fused to His-tag at N-terminus, was expressed in E Coli

Product Categories/Family for EDAR recombinant protein

Signal Transduction

References

Yan M., et al. (2000) Science 290:523-527

NCBI and Uniprot Product Information

• NCBI GI #: 11641231
• NCBI GeneID: 10913
• NCBI Accession #: NP_071731
• NCBI GenBank Nucleotide #: NM_022336.3
• UniProt Accession #: Q9UNE0; Q52LL5; Q9UND9; B2R9H2; B4DLC5; D3DX74; E9PC98
• Molecular Weight: 48.2 kDa (445aa)
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member EDAR
• NCBI Official Synonym Full Names: ectodysplasin A receptor
• NCBI Official Symbol: EDAR
• NCBI Official Synonym Symbols: DL; ED3; ED5; ED1R; EDA3; HRM1; EDA1R; ECTD10A; ECTD10B; EDA-A1R
• NCBI Protein Information: tumor necrosis factor receptor superfamily member EDAR
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member EDAR
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: EDAR
• UniProt Synonym Gene Names: DL

NCBI Description

This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia. [provided by RefSeq, Jul 2008]

Uniprot Description

Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.