TPO active protein
Rat TPO
Reactivity
Rat
Purity
> 98% by SDS-PAGE & HPLC analyses
Synonyms
TPO; Rat TPO; DDX4; VASA; TPO active protein
Host
E Coli
Reactivity
Rat
Purity/Purification
> 98% by SDS-PAGE & HPLC analyses
Form/Format
Lyophilized
Sequence
SPVPPACDPR LLNKLLRDSY LLHSRLSQCP DVNPLSIPVL LPAVDF SLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL G QLSGQVRLL LGALQGLLGT QLPPQGRTTA HKDPSALFLS LQQLLRG KVR FLLLVEGPAL CVRRTLPTTA VPSRTSQLLT LNKF
Sequence Length
326
Biological Activity
Determined by its ability to stimulate the proliferation of human MO7e cells. The expected B>ED50 is <= 0.2 ng/ml, corresponding to a specific activity of >= 5 x 106 units/mg.
Related Product Information for TPO active protein
TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant rat TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein.
Product Categories/Family for TPO active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
34,556 Da
NCBI Official Full Name
thrombopoietin
NCBI Official Synonym Full Names
thrombopoietin
NCBI Official Symbol
Thpo
NCBI Protein Information
thrombopoietin
UniProt Protein Name
Thrombopoietin
Protein Family
UniProt Gene Name
Thpo
UniProt Entry Name
TPO_RAT
NCBI Description
lineage-specific cytokine; important for proliferation and development of megakaryocytes and platelets; may be the major regulator of circulating platelets [RGD, Feb 2006]
Uniprot Description
Function: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Subcellular location: Secreted.
Domain: Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.
Sequence similarities: Belongs to the EPO/TPO family.
Research Articles on TPO
Similar Products
Product Notes
The TPO thpo (Catalog #AAA691621) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Rat TPO reacts with Rat and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: SPVPPACDPR LLNKLLRDSY LLHSRLSQCP DVNPLSIPVL LPAVDF SLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL G QLSGQVRLL LGALQGLLGT QLPPQGRTTA HKDPSALFLS LQQLLRG KVR FLLLVEGPAL CVRRTLPTTA VPSRTSQLLT LNKF. It is sometimes possible for the material contained within the vial of "TPO, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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