Rabbit anti-Rat, mouse Thpo Polyclonal Antibody | anti-Thpo antibody

Thpo Antibody

Cat. Num. AAA7006730

• Reactivity: Rat, mouse
• Applications: ELISA, Western Blot
• Purity: >95%,Protein G purified
• Synonyms: Thpo; Polyclonal Antibody; Thpo Antibody; Thrombopoietin; anti-Thpo antibody

• Host: Rabbit
• Reactivity: Rat, mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%,Protein G purified
• Form/Format: Liquid
• Sequence Length: 326

• Applicable Applications for anti-Thpo antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Recombinant rat Thrombopoietin protein
• Conjugation: Non-conjugated
• Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Preparation and Storage: Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.

Western Blot (WB)

(Western blotAll lanes: Thpo antibody at 4ug/mlLane 1: Mouse liver tissueLane 2: 293T whole cell lysateSecondaryGoat polyclonal to Rabbit IgG at 1/10000 dilutionPredicted band size: 35 kDaObserved band size: 35 kDa)

Related Product Information for anti-Thpo antibody

Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

NCBI and Uniprot Product Information

• NCBI GI #: 13592113
• NCBI GeneID: 81811
• NCBI Accession #: NP_112395.1
• NCBI GenBank Nucleotide #: NM_031133.2
• UniProt Accession #: P49745
• Molecular Weight: 34,556 Da
• NCBI Official Full Name: thrombopoietin
• NCBI Official Synonym Full Names: thrombopoietin
• NCBI Official Symbol: Thpo
• NCBI Protein Information: thrombopoietin
• UniProt Protein Name: Thrombopoietin
• Protein Family: Thrombopoietin
• UniProt Gene Name: Thpo
• UniProt Entry Name: TPO_RAT

NCBI Description

lineage-specific cytokine; important for proliferation and development of megakaryocytes and platelets; may be the major regulator of circulating platelets [RGD, Feb 2006]

Uniprot Description

THPO: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. Defects in THPO are the cause of thrombocythemia type 1 (THCYT1). A myeloproliferative disorder characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications. Belongs to the EPO/TPO family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Cell cycle regulation; Cytokine

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; hormone activity; receptor binding

Biological Process: cell proliferation; myeloid cell differentiation; positive regulation of cell proliferation; positive regulation of megakaryocyte differentiation; positive regulation of protein amino acid phosphorylation; positive regulation of protein kinase B signaling cascade; response to lipopolysaccharide