Testing Data
TPO active protein
Rat TPO
Cross Reactivity: Human
Cross Reactivity: Human
Testing Data
Testing Data
NCBI and Uniprot Product Information
Uniprot Description
THPO: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. Defects in THPO are the cause of thrombocythemia type 1 (THCYT1). A myeloproliferative disorder characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications. Belongs to the EPO/TPO family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; Cytokine; Secreted; Secreted, signal peptide
Cellular Component: extracellular space; extracellular region
Molecular Function: hormone activity; cytokine activity; receptor binding
Biological Process: cell proliferation; positive regulation of protein kinase B signaling cascade; positive regulation of cell proliferation; response to lipopolysaccharide; myeloid cell differentiation; positive regulation of megakaryocyte differentiation; positive regulation of protein amino acid phosphorylation
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Product Notes
The TPO thpo (Catalog #AAA695938) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Rat TPO reacts with Species Reactivity: Rat Cross Reactivity: Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: SPVPPACDP RLLNKLLRD SYLLHSRLS QCPDVNPLS IPVLLPAVD FSLGEWKTQ TEQSKAQDI LGAVSLLLE GVMAARGQL EPSCLSSLL GQLSGQVRL LLGALQGLL GTQLPPQGR TTAHKDPSA LFLSLQQLL RGKVRFLLL VEGPALCVR RTLPTTAVP SRTSQLLTL NKF. It is sometimes possible for the material contained within the vial of "TPO, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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