SCF active protein
Rat SCF
NCBI and Uniprot Product Information
NCBI Description
soluble growth factor that activates c-kit tyrosine kinase receptor; important for signaling in spermatogenesis; putative regulator of Leydig cell development [RGD, Feb 2006]
Uniprot Description
Function: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Subunit structure: Homodimer, non-covalently linked
Probable. Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation.
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
By similarity. Isoform 2: Cell membrane; Single-pass type I membrane protein
By similarity. Cytoplasm › cytoskeleton
By similarity. Soluble KIT ligand: Secreted
By similarity.
Developmental stage: Acts in the early stages of hematopoiesis.
Post-translational modification: A soluble form is produced by proteolytic processing of isoform 1 in the extracellular domain.The identity of N- and O-linked saccharides are not reported in Ref.3. The O-linked polysaccharides are probably the mucin type linked to GalNAc.
Sequence similarities: Belongs to the SCF family.
Research Articles on SCF
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Product Notes
The SCF kitlg (Catalog #AAA692096) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Rat SCF reacts with Rat and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MQEICRNPVT DNVKDITKLV ANLPNDYMIT LNYVAGMDVL PSHCWL RDMV THLSVSLTTL LDKFSNISEG LSNYSIIDKL GKIVDDLVAC M EENAPKNVK ESLKKPETRN FTPEEFFSIF NRSIDAFKDF MVASDTS DCV LSSTLGPEKD SRVSVTKPFM LPPVA. It is sometimes possible for the material contained within the vial of "SCF, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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