Prolactin Active Protein | Prl active protein

Rat Prolactin

Cat. Num. AAA691762

• Gene Names: Prl; PRLB; Prol; PRLSD1; Prl1a1; RNPROL; RATPRLSD1
• Reactivity: Rat
• Purity: > 98% by SDS-PAGE and HPLC analysis
• Synonyms: Prolactin; Rat Prolactin; Recombinant Rat Prolactin; Prl active protein

• Host: E Coli
• Reactivity: Rat
• Purity/Purification: > 98% by SDS-PAGE and HPLC analysis
• Form/Format: Lyophilized
• Sequence: MLPVCSGGDC QTPLPELFDR VVMLSHYIHT LYTDMFIEFD KQYVQD REFI AKAINDCPTS SLATPEDKEQ AQKVPPEVLL NLILSLVHSW N DPLFQLITG LGGIHEAPDA IISRAKEIEE QNKRLLEGIE KIISQAY PEA KGNEIYLVWS QLPSLQGVDE ESKDLAFYNN IRCLRRDSHK VD NYLKFLRC QIVHKNNC
• Sequence Length: 226

• Endotoxin Level: < 0.1 ng/ug of Prolactin
• Biological Activity: Determined by its ability to induce the proliferation of rat Nb2-11 cells in the concentration range of 0.1-1.0 ng/ml.

Related Product Information for Prl active protein

The neuroendocrine pituitary hormone Prolactin (PRL), also known as lactotrophin, mamotrophin, luteotropic hormone (LTH), or luteotropin, is a secreted hormone that affects reproduction and homeostasis in vertebrates. The functions of PRL can be placed in six broad categories: 1) reproduction and lactation; 2) growth and development; 3) endocrinology and metabolism; 4) brain and behavior; 5) immunomodulation; and 6) electrolyte balance. PRL is secreted by the anterior pituitary gland, mammary gland, placenta, brain, uterus, decidua, dermal fibroblasts, B cells, T cells, NK cells, and some breast cancer cell lines. Although the major form of PRL is a 23 kDa monomeric protein, splice variants of 14, 16, and 22 kDa have been identified. PRL has also been found to be glycosylated, phosphorylated, dimerized, and polymerized. Glycosylation, phosphorylation, dimerization, or polymerization of PRL result in lower activity. Cell activation by PRL is mediated by a single chain membranebound protein belonging to the class 1 cytokine superfamily. The PRL receptor (PRL R) contains an extracellular, transmembrane, and intracellular domain. Transcriptional regulation of the PRL R gene results in several different speciesdependent isoforms of PRL R being produced. Although the cytoplasmic domains of the different isoforms vary in length and composition, their extracellular domains are identical. In rats, three major PRL receptor isoforms have been described, a short (291 amino acid), an intermediate (393 amino acid), and a long (591 amino acid). PRL receptors are found in mammary tissue, pituitary gland, brain, heart, lung thymus, spleen, liver, pancreas, kidney, adrenal gland, uterus, skeletal muscle, and skin. A soluble form of PRLR containing the 206 NH2-terminal amino acids of the extracellular domain is secreted by mammary epithelial cells and is found in milk. Binding of the transmembrane PRL R results in ligand dimerization followed by binding and phosphorylation of Jak2. Jak2 then phosphorylates STAT and the long form of PRL R. Csrc, fyn, and the Ras/Raf/MAP kinase pathway have also been found to be activated upon PRL R ligand binding.

Product Categories/Family for Prl active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 6981404
• NCBI GeneID: 24683
• NCBI Accession #: NP_036761.1
• NCBI GenBank Nucleotide #: NM_012629.1
• UniProt Accession #: P01237; P70520
• Molecular Weight: 22.6 kDa
• NCBI Official Full Name: prolactin
• NCBI Official Synonym Full Names: prolactin
• NCBI Official Symbol: Prl
• NCBI Official Synonym Symbols: PRLB; Prol; PRLSD1; Prl1a1; RNPROL; RATPRLSD1
• NCBI Protein Information: prolactin; prolactin family 1, subfamily a, member 1
• UniProt Protein Name: Prolactin
• Protein Family: Prolactin
• UniProt Gene Name: Prl
• UniProt Synonym Gene Names: PRL
• UniProt Entry Name: PRL_RAT

NCBI Description

induces lactation; may facilitate decidual growth and placentation; promotes prostate epithelial cell proliferation [RGD, Feb 2006]

Uniprot Description

Function: Prolactin acts primarily on the mammary gland by promoting lactation.

Subcellular location: Secreted.

Sequence similarities: Belongs to the somatotropin/prolactin family.

Sequence caution: The sequence described in Ref.6 differs from that shown. Reason: Differs at a number of positions and in the total number of residues.