Prolactin (PRL) Recombinant Protein | PRL recombinant protein

Prolactin (PRL)

Cat. Num. AAA517483

• Applications: Cell Assay
• Synonyms: Prolactin (PRL); Luterotropic hormone; Lutetropin; Mammotropin; PRL; PRL recombinant protein

• Host: E Coli
• Form/Format: Lyophilized from a concentrated solution in PBS.

• Applicable Applications for PRL recombinant protein: Cell Assay
• Species: Human
• Endotoxin Level: <1.0EU/ug of recombinant protein as determined by the LAL method
• Reconstitution: It is recommended to reconstitute lyophilized PRL in sterile distilled water to no less than 100ug/ml, which can then be further diluted to other aqueous solutions.
• Preparation and Storage: The lyophilized protein is stable for at least one year from date of receipt at -70 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree -8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Activity

(Sample Cell Assay Data: Determined by its ability to induce the proliferation of rat Nb2-11 cells in the concentration range of 0.1-1.0 ng/ml.)

SDS-Page

(Purity: Recombinant Human Prolactin (PRL) resolved on a 15% SDS-PAGE gel under reducing conditions and stained with Coomassie Brilliant Blue G-250)

Related Product Information for PRL recombinant protein

Recombinant Human Prolactin (PRL) was expressed in E Coli cells. The protein accession number is P01236
Synthesized primarily by the pituitary gland, prolactin is a neuroendocrine hormone that functions to promote and maintain lactation and has also been shown to play a role in breast cancer development, regulation of reproductive function and immune-regulation. While Human prolactin shares only 60% and 63% amino acid sequence identity with mouse and rat prolactin, respectively, the human prolactin receptor can be activated by Rat PRL. abm's Recombinant Human PRL is a single, non-glycosylated polypeptide chain with a molecular mass of 23kDa.

Product Categories/Family for PRL recombinant protein

Growth Factors; Cancer

NCBI and Uniprot Product Information

• NCBI GI #: 254675133
• NCBI GeneID: 5617
• NCBI Accession #: NP_001157030.1
• NCBI GenBank Nucleotide #: NM_001163558.2
• UniProt Accession #: P01236; Q15199; Q92996
• Molecular Weight: 25,876 Da
• NCBI Official Full Name: prolactin
• NCBI Official Synonym Full Names: prolactin
• NCBI Official Symbol: PRL
• NCBI Protein Information: prolactin; decidual prolactin
• UniProt Protein Name: Prolactin
• Protein Family: Prolactin
• UniProt Gene Name: PRL
• UniProt Synonym Gene Names: PRL
• UniProt Entry Name: PRL_HUMAN

NCBI Description

This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]

Uniprot Description

prolactin: Prolactin acts primarily on the mammary gland by promoting lactation. Belongs to the somatotropin/prolactin family.

Protein type: Secreted; Cytokine; Secreted, signal peptide; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6p22.3

Cellular Component: extracellular region

Molecular Function: protein binding; prolactin receptor binding; hormone activity

Biological Process: lactation; cell proliferation; cell surface receptor linked signal transduction; regulation of multicellular organism growth; positive regulation of JAK-STAT cascade; female pregnancy