PRDX 4 Active Protein | PRDX4 active protein

Human Recombinant PRDX 4

Cat. Num. AAA844531

• Gene Names: PRDX4; PRX-4; AOE372; AOE37-2; HEL-S-97n
• Applications: SDS-Page
• Purity: >=90%
• Synonyms: PRDX 4; Human Recombinant PRDX 4; Peroxiredoxin 4; PRX-4; AOE37-2; PRDX4.; PRDX4 active protein

• Host: E Coli
• Purity/Purification: >=90%
• Form/Format: 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol. ; Appearance: Liquid
• Concentration: 1 mg/ml (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MWETEERPRT REEECHFYAG GQVYPGEASR VSVADHSLHL SKAKISKPAP YWEGTAVIDG EFKELKLTDY RGKYLVFFFY PLDFTFVCPT EIIAFGDRLE EFRSINTEVV ACSVDSQFTH LAWINTPRRQ GGLGPIRIPL LSDLTHQISK DYGVYLEDSG HTLRGLFIID DKGILRQITL NDLPVGRSVD ETLRLVQAFQ YTDKHGEVCP AGWKPGSETI IPDPAGKLKY FDKLN
• Sequence Length: 271

• Applicable Applications for PRDX4 active protein: SDS-PAGE
• Biological Activity: Specific activity: approximately 230-310 pmole/min/ug. Enzymatic activity was confirmed by measuring the remaining peroxide after incubation of PRDX 4 and peroxide for 20 min at room temperature.
• Unit Definition: Specific activity is defined as the amount of hydroperoxide that 1 ug of enzyme can reduce at 25 degree C for 1 minute.
• Handling: Centrifuge the vial prior to opening.
• Preparation and Storage: At -80 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for PRDX4 active protein

Background: Peroxiredoxin-4 in humans is encoded by the PRDX4 gene. The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. It is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappa B.

Product Categories/Family for PRDX4 active protein

Proteins and Enzymes; Proteins and Enzymes (A-Z)  

NCBI and Uniprot Product Information

• NCBI GI #: 5453549
• NCBI GeneID: 10549
• NCBI Accession #: NP_006397.1
• NCBI GenBank Nucleotide #: NM_006406.1
• UniProt Accession #: Q13162; Q6FHT3
• Molecular Weight: 28.8 kDa
• NCBI Official Full Name: peroxiredoxin-4
• NCBI Official Synonym Full Names: peroxiredoxin 4
• NCBI Official Symbol: PRDX4
• NCBI Official Synonym Symbols: PRX-4; AOE372; AOE37-2; HEL-S-97n
• NCBI Protein Information: peroxiredoxin-4
• UniProt Protein Name: Peroxiredoxin-4
• Protein Family: Peroxiredoxin
• UniProt Gene Name: PRDX4
• UniProt Synonym Gene Names: AOE37-2; Prx-IV
• UniProt Entry Name: PRDX4_HUMAN

NCBI Description

The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]

Uniprot Description

PRDX4: Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. Belongs to the AhpC/TSA family.

Protein type: Mitochondrial; Secreted; Oxidoreductase; Secreted, signal peptide; EC 1.11.1.15

Chromosomal Location of Human Ortholog: Xp22.11

Cellular Component: extracellular space; smooth endoplasmic reticulum; mitochondrion; nucleus; cytosol

Molecular Function: protein binding; protein homodimerization activity; thioredoxin peroxidase activity

Biological Process: extracellular matrix organization and biogenesis; protein maturation via protein folding; 4-hydroxyproline metabolic process; cell redox homeostasis; male gonad development; spermatogenesis; I-kappaB phosphorylation