Uteroglobin Active Protein | mSCGB1A1 active protein
Recombinant Mouse Uteroglobin
Gene Names
Scgb1a1; UG; UGB; Utg; CC10; CC16; CCSP; PCB-BP
Purity
Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Synonyms
Uteroglobin; Recombinant Mouse Uteroglobin; SCGB1A1 Mouse; Uteroglobin Mouse Recombinant; Clara cell 17 kDa protein; Clara cell phospholipid-binding protein; CCPBP; Clara cells 10 kDa secretory protein; CC10; PCB-binding protein; Secretoglobin family 1A member 1; Scgb1a1; Ugb; Utg; UG; CC16; CCSP; PCB-BP; mSCGB1A1 active protein
Host
E Coli
Purity/Purification
Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Form/Format
The Uteroglobin protein was lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sequence
DICPGFLQVL EALLMESESG YVASLKPFNP GSDLQNAGTQ LKRLVDTLPQ ETRINIMKLT EKILTSPLCK QDLRF
Sequence Length
96
Solubility
It is recommended to reconstitute the lyophilized SCGB1A1 in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
The ED50 as determined by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cells is less than 5.0 ug/ml, corresponding to a specific activity of > 200 IU/mg.
Preparation and Storage
Lyophilized Uteroglobin although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution SCGB1A1 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Related Product Information for mSCGB1A1 active protein
Description: Uteroglobin Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 75 amino acids and having a molecular mass of 16.7kDa.The SCGB1A1 is purified by proprietary chromatographic techniques.
Introduction: Uteroglobin (SCGB1A1) which belongs to the Secretoglobin (SCGBs) superfamily, is a multifunctional protein that exerts anti-inflammatory and anti-tumorigenic effects by binding small hydrophobic molecules such as phospholipids and prostaglandins. Uteroglobin is involved in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. SCGB1A1 is expressed by Clara cells, the non-ciliated, non-mucous secretory cells predominant in lung bronchioles, and by other epithelia which communicate with the external environment. On top of sequestering pro-inflammatory mediators and carcinogens, Uteroglobin is implicated in the inhibition of cell migration and invasion, platelet aggregation, and T cell differentiation. SCGB1A1 gene defects are associated with a susceptibility to asthma.
Introduction: Uteroglobin (SCGB1A1) which belongs to the Secretoglobin (SCGBs) superfamily, is a multifunctional protein that exerts anti-inflammatory and anti-tumorigenic effects by binding small hydrophobic molecules such as phospholipids and prostaglandins. Uteroglobin is involved in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. SCGB1A1 is expressed by Clara cells, the non-ciliated, non-mucous secretory cells predominant in lung bronchioles, and by other epithelia which communicate with the external environment. On top of sequestering pro-inflammatory mediators and carcinogens, Uteroglobin is implicated in the inhibition of cell migration and invasion, platelet aggregation, and T cell differentiation. SCGB1A1 gene defects are associated with a susceptibility to asthma.
Product Categories/Family for mSCGB1A1 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
10,519 Da
NCBI Official Full Name
uteroglobin
NCBI Official Synonym Full Names
secretoglobin, family 1A, member 1 (uteroglobin)
NCBI Official Symbol
Scgb1a1
NCBI Official Synonym Symbols
UG; UGB; Utg; CC10; CC16; CCSP; PCB-BP
NCBI Protein Information
uteroglobin; Blastokinin; CCPBP; PCB-binding protein; clara cell 17 kDa protein; clara cell phospholipid-binding protein; clara cell secretory protein; clara cells 10 kDa secretory protein; secretoglobin family 1A member 1
UniProt Protein Name
Uteroglobin
Protein Family
UniProt Gene Name
Scgb1a1
UniProt Synonym Gene Names
Cc10; Ugb; Utg; CCPBP; CC10
UniProt Entry Name
UTER_MOUSE
Uniprot Description
SCGB1A1: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2. Belongs to the secretoglobin family.
Protein type: Secreted, signal peptide; Secreted; Inhibitor; Cell cycle regulation
Cellular Component: extracellular space; rough endoplasmic reticulum; endoplasmic reticulum; cytoplasm; extracellular region; nuclear envelope; intracellular; secretory granule
Molecular Function: phospholipase A2 inhibitor activity
Biological Process: negative regulation of interleukin-4 production; negative regulation of interleukin-13 production; negative regulation of T cell proliferation; response to cytokine stimulus; negative regulation of interferon-gamma production; regulation of inflammatory response; negative regulation of interleukin-5 production; negative regulation of transcription from RNA polymerase II promoter; regulation of mRNA stability; signal transduction
Research Articles on mSCGB1A1
1. Suggest role for Scgb1a1(+) cells in the generation of p63(+) cells in the damaged lung parenchyma.
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Product Notes
The mSCGB1A1 scgb1a1 (Catalog #AAA145600) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: DICPGFLQVL EALLMESESG YVASLKPFNP GSDLQNAGTQ LKRLVDTLPQ ETRINIMKLT EKILTSPLCK QDLRF. It is sometimes possible for the material contained within the vial of "Uteroglobin, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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