MCP-5 (CCL12) active protein
Mouse MCP-5 (CCL12)
Gene Names
Cma1; Mcp5; Mcp-5; Mcpt5; MMCP-5
Reactivity
Mouse
Purity
> 99% (SDS-PAGE; HPLC)
Synonyms
MCP-5 (CCL12); Mouse MCP-5 (CCL12); Recombinant Murine MCP-5; MCP-5 (CCL12) active protein
Host
E Coli
Reactivity
Mouse
Purity/Purification
> 99% (SDS-PAGE; HPLC)
Form/Format
Lyophilized
Sequence
GPDAVSTPVT CCYNVVKQKI HVRKLKSYRR ITSSQCPREA VIFRTI LDKE ICADPKEKWV KNSINHLDKT SQTFILEPSC LG
Sequence Length
260
Endotoxin Level
< 0.1 ng/ug of MCP-5
Biological Activity
Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10.0-50.0 ng/ml.
Related Product Information for MCP-5 (CCL12) active protein
MCP-5 or CCL12 is a cloned mouse CC chemokine most closely related to human MCP1 (66% amino acid sequence identity in the mature protein). Mouse MCP-5 encodes a 104 amino acid residue precursor protein with a 22 aa residue predicted hydrophobic signal sequence that is cleaved to generate a 82 aa residue mature protein. MCP-5 is expressed constitutively in the thymus and lymph nodes. Under inflammatory conditions, its expression is also induced in activated macrophages and mast cells. The gene for mouse MCP1 has been mapped to the CC chemokine cluster on chromosome 11. Recombinant MCP-5 has been shown to be a potent chemoattractant for monocytes and lymphocytes but not neutrophils. At high concentrations, MCP-5 will also chemoattract eosinophils. MCP-5 has been found to be a functional ligand for CCR2 but not CCR1, CCR3 or CCR5.
Product Categories/Family for MCP-5 (CCL12) active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
9.2 kDa
NCBI Official Full Name
chymase
NCBI Official Synonym Full Names
chymase 1, mast cell
NCBI Official Symbol
Cma1
NCBI Official Synonym Symbols
Mcp5; Mcp-5; Mcpt5; MMCP-5
NCBI Protein Information
chymase; alpha-chymase; mast cell chymase 1; mast cell protease 5; mast cell protease I
UniProt Protein Name
Chymase
UniProt Gene Name
Cma1
UniProt Synonym Gene Names
Mcpt5; mMCP-5
UniProt Entry Name
CMA1_MOUSE
Uniprot Description
Function: Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
Catalytic activity: Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa.
Subcellular location: Secreted. Cytoplasmic granule. Note: Secretory granules. Ref.6
Tissue specificity: Mast cells.
Sequence similarities: Belongs to the peptidase S1 family. Granzyme subfamily.Contains 1 peptidase S1 domain.
Sequence caution: The sequence CAA48705.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on MCP-5 (CCL12)
Similar Products
Product Notes
The MCP-5 (CCL12) cma1 (Catalog #AAA691920) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse MCP-5 (CCL12) reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: GPDAVSTPVT CCYNVVKQKI HVRKLKSYRR ITSSQCPREA VIFRTI LDKE ICADPKEKWV KNSINHLDKT SQTFILEPSC LG. It is sometimes possible for the material contained within the vial of "MCP-5 (CCL12), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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