IL-31 active protein
Mouse IL-31
Gene Names
Il31; 1700013B14Rik
Reactivity
Mouse
Purity
> 98% (SDS-PAGE; HPLC)
Synonyms
IL-31; Mouse IL-31; Recombinant Murine IL-31; IL-31 active protein
Host
E Coli
Reactivity
Mouse
Purity/Purification
> 98% (SDS-PAGE; HPLC)
Form/Format
Lyophilized
Sequence
MTCSLSFGAP ISKEDLRTTI DLLKQESQDL YNNYSIKQAS GMSADE SIQL PCFSLDREAL TNISVIIAHL EKVKVLSENT VDTSWVIRWL T NISCFNPLN LNISVPGNTD ESYDCKVFVL TVLKQFSNCM AELQAKD NTT C
Sequence Length
163
Endotoxin Level
< 0.1 ng/g of IL-31
Biological Activity
Testing in progress.
Related Product Information for IL-31 active protein
IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant murine IL-31 is a 15.8 kDa protein containing 140 amino acid residues.
Product Categories/Family for IL-31 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
15.8 kDa
NCBI Official Full Name
interleukin-31
NCBI Official Synonym Full Names
interleukin 31
NCBI Official Symbol
Il31
NCBI Official Synonym Symbols
1700013B14Rik
NCBI Protein Information
interleukin-31; IL-31
UniProt Protein Name
Interleukin-31
UniProt Gene Name
Il31
UniProt Synonym Gene Names
IL-31
UniProt Entry Name
IL31_MOUSE
Uniprot Description
Function: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity. Ref.1
Subcellular location: Secreted
Probable.
Miscellaneous: Il31 transgenic mice develop dermatitis. A similar phenotype is caused by local delivery of Il31.
Research Articles on IL-31
Similar Products
Product Notes
The IL-31 il31 (Catalog #AAA691725) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse IL-31 reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MTCSLSFGAP ISKEDLRTTI DLLKQESQDL YNNYSIKQAS GMSADE SIQL PCFSLDREAL TNISVIIAHL EKVKVLSENT VDTSWVIRWL T NISCFNPLN LNISVPGNTD ESYDCKVFVL TVLKQFSNCM AELQAKD NTT C. It is sometimes possible for the material contained within the vial of "IL-31, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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