IGF-1 active protein
Mouse IGF-1
Gene Names
Igf1; Igf-1; Igf-I; C730016P09Rik
Reactivity
Mouse
Purity
> 98% (SDS-PAGE; HPLC)
Synonyms
IGF-1; Mouse IGF-1; Recombinant Murine IGF-I; IGF-1 active protein
Host
E Coli
Reactivity
Mouse
Purity/Purification
> 98% (SDS-PAGE; HPLC)
Form/Format
Lyophilized
Sequence
GPETLCGAEL VDALQFVCGP RGFYFNKPTG YGSSIRRAPQ TGIVDE CCFR SCDLRRLEMY CAPLKPTKAA
Sequence Length
153
Endotoxin Level
< 0.1 ng/g of IGF-I
Biological Activity
The ED50 was determined a cell proliferation assay using FDC-P1 cells is <= 2.0 ng/ml, corresponding to a specific activity of>= 5 x 105 units/mg.
Related Product Information for IGF-1 active protein
he IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant murine IGF-I is a 7.6 kDa globular protein containing amino acids including 3 intra-molecular disulfide bonds.
Product Categories/Family for IGF-1 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
7.6 kDa
NCBI Official Full Name
insulin-like growth factor I isoform 4 preproprotein
NCBI Official Synonym Full Names
insulin-like growth factor 1
NCBI Official Symbol
Igf1
NCBI Official Synonym Symbols
Igf-1; Igf-I; C730016P09Rik
NCBI Protein Information
insulin-like growth factor I; somatomedin
UniProt Protein Name
Insulin-like growth factor I
UniProt Gene Name
Igf1
UniProt Synonym Gene Names
Igf-1; IGF-I
UniProt Entry Name
IGF1_MOUSE
Uniprot Description
Function: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation
By similarity.
Subcellular location: Secreted.
Sequence similarities: Belongs to the insulin family.
Sequence caution: The sequence AAH12409.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
Research Articles on IGF-1
Similar Products
Product Notes
The IGF-1 igf1 (Catalog #AAA691927) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse IGF-1 reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: GPETLCGAEL VDALQFVCGP RGFYFNKPTG YGSSIRRAPQ TGIVDE CCFR SCDLRRLEMY CAPLKPTKAA. It is sometimes possible for the material contained within the vial of "IGF-1, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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