GDNF active protein
Mouse GDNF
NCBI and Uniprot Product Information
Uniprot Description
Function: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
Subunit structure: Homodimer; disulfide-linked.
Subcellular location: Secreted.
Tissue specificity: Expressed in both the central nervous system (CNS) and in non-CNS tissues. Expressed in a highly dynamic pattern in the anterior neuroectoderm during the early stages of neurogenesis between E7.5 and E10.5. Beginning at E10.5, expression begins in mesenchymal tissues of several organs including the digestive tract, kidney, testis, frontonasal mass, tooth primordium, tongue, mandible, whisker follicles, ear, eye, limb bud and in distinct regions of the brain. Also expressed in the heart, ileum, liver and muscle. Ref.2 Ref.4
Developmental stage: Expressed begins by E7.5, reaches its peak around E9.5 and declines considerably after E10.5. Ref.2
Induction: Expression in C6 glioma cells was transiently induced by treatment with phorbol myristate acetate (PMA), but not by forskolin. Ref.3
Sequence similarities: Belongs to the TGF-beta family. GDNF subfamily.
Research Articles on GDNF
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Product Notes
The GDNF gdnf (Catalog #AAA691948) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse GDNF reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTA IHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS R RLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCI. It is sometimes possible for the material contained within the vial of "GDNF, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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