Western Blot (WB)
(Western blot analysis on COLO205 cell lysate using STEA3 Antibody)
STEA3 Antibody | anti-STEA3 antibody
STEA3 Antibody
Gene Names
STEAP3; STMP3; TSAP6; pHyde; AHMIO2; dudlin-2; dudulin-2
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunofluorescence, Immunocytochemistry
Purity
Immunogen affinity purified
Synonyms
STEA3; STEA3 Antibody; 1010001D01Rik; dudlin 2; dudlin-2; dudulin 2; Dudulin-2; hpHyde; hTSAP6; Metalloreductase STEAP3; pHyde; six transmembrane prostate protein 3; Six-transmembrane epithelial antigen of prostate 3; STEAP family member 3; STEAP3; STMP3; TSAP6; tumor su; anti-STEA3 antibody
Reactivity
Human, Mouse, Rat
Specificity
STEA3 Antibody detects endogenous levels of STEA3
Purity/Purification
Immunogen affinity purified
Form/Format
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Sequence Length
488
Applicable Applications for anti-STEA3 antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
Application Notes
WB: 1:500-1:2000
IF/ICC: 1:100-1:500
IF/ICC: 1:100-1:500
Immunogen
A synthesized peptide derived from human STEA3
Preparation and Storage
Store at-20 degree C for 1 year
Western Blot (WB)
(Western blot analysis on COLO205 cell lysate using STEA3 Antibody)
Western Blot (WB)
(Western blot analysis on COLO205 cell lysate using STEA3 Antibody)
Related Product Information for anti-STEA3 antibody
STEAP3 a multi-pass membrane protein induced directly by p53. Plays an important role in facilitating exosome secretion. Enhances secretion in the DNA damage-induced p53-dependent exosomal secretory pathway. Localizes to vesicular-like structures at the plasma membrane and around the nucleus. Highly expressed in hematopoietic tissues where it localizes to the specialized endosome. An endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NAD(+) as acceptor.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
54kDa
NCBI Official Full Name
metalloreductase STEAP3 isoform b
NCBI Official Synonym Full Names
STEAP3 metalloreductase
NCBI Official Symbol
STEAP3
NCBI Official Synonym Symbols
STMP3; TSAP6; pHyde; AHMIO2; dudlin-2; dudulin-2
NCBI Protein Information
metalloreductase STEAP3
UniProt Protein Name
Metalloreductase STEAP3
UniProt Gene Name
STEAP3
UniProt Synonym Gene Names
TSAP6; hTSAP6; hpHyde
NCBI Description
This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Uniprot Description
Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe3+ to Fe2+. Can also reduce of Cu2+ to Cu1+, suggesting that it participates in copper homeostasis. Uses NADP+ as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.
Research Articles on STEA3
1. TSAP6 over expression is associated with poor survival in metastatic high-grade serous carcinoma.
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Product Notes
The STEA3 steap3 (Catalog #AAA8511044) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The STEA3 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's STEA3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC). WB: 1:500-1:2000 IF/ICC: 1:100-1:500. Researchers should empirically determine the suitability of the STEA3 steap3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "STEA3, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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