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Testing Data

LIX / CXCL6 Active Protein | LIX active protein

Murine LIX / CXCL6 (93 a.a.)

Gene Names
Cxcl5; LIX; GCP-2; Scyb5; Scyb6; ENA-78; AMCF-II
Reactivity
Species Reactivity: Mouse
Cross Reactivity: Human
Purity
Above 98% as determined by SDS-PAGE Analysis.
Synonyms
LIX / CXCL6; Murine LIX / CXCL6 (93 a.a.); Recombinant Murine LIX (CXCL6) [92a.a]; LIX active protein
Ordering
For Research Use Only!
Host
E Coli
Reactivity
Species Reactivity: Mouse
Cross Reactivity: Human
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Sequence
APSSVIAAT ELRCVCLTV TPKINPKLI ANLEVIPAG PQCPTVEVI AKLKNQKEV CLDPEAPVI KKIIIQKIL GSDKKKAKR NALAVERTA SVQ
Biological Activity
Determined by its ability to chemoattract human neutrophils using a concentration range of 10-100 ng/ml.
Cell Type
Monocytes and Macrophages, Endothelial Cells
Preparation and Storage
At -20 degree C

Testing Data

Testing Data
Related Product Information for LIX active protein
LIX is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. LIX is a chemoattractant for neutrophils. The two naturally occurring variants of LIX; LIX 1-78 (GCP-2) and LIX 9-78 (GCP-2), contain 78 and 70 amino acid residues, respectively. LIX contains the four conserved cysteine residues present in CXC chemokines, and also contains the ‘ELR' motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors. Recombinant murine LIX is a 9.8 kDa protein containing 92 amino acid residues.
Product Categories/Family for LIX active protein

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
14,235 Da
NCBI Official Full Name
C-X-C motif chemokine 5
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 5
NCBI Official Symbol
Cxcl5
NCBI Official Synonym Symbols
LIX; GCP-2; Scyb5; Scyb6; ENA-78; AMCF-II
NCBI Protein Information
C-X-C motif chemokine 5; cytokine LIX; small-inducible cytokine B5; granulocyte chemotactic protein-2; small inducible cytokine B subfamily, member 5; small inducible cytokine subfamily B, member 15
UniProt Protein Name
C-X-C motif chemokine 5
UniProt Gene Name
Cxcl5
UniProt Synonym Gene Names
Scyb5
UniProt Entry Name
CXCL5_MOUSE

NCBI Description

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils and to have homeostatic and inflammatory functions. In mouse, deficiency of this gene is associated with increased lung inflammation that is neutrophil-dependent. [provided by RefSeq, May 2013]

Uniprot Description

CXCL6: Chemotactic for neutrophil granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity; CXCR chemokine receptor binding; cytokine activity

Biological Process: G-protein coupled receptor protein signaling pathway; organ regeneration; cytokine production; positive regulation of JAK-STAT cascade; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; immune response; chemotaxis; inflammatory response; regulation of chemokine production; leukocyte homeostasis; regulation of cell proliferation

Research Articles on LIX

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Product Notes

The LIX cxcl5 (Catalog #AAA695757) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Murine LIX / CXCL6 (93 a.a.) reacts with Species Reactivity: Mouse Cross Reactivity: Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: APSSVIAAT ELRCVCLTV TPKINPKLI ANLEVIPAG PQCPTVEVI AKLKNQKEV CLDPEAPVI KKIIIQKIL GSDKKKAKR NALAVERTA SVQ. It is sometimes possible for the material contained within the vial of "LIX / CXCL6, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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