TRAIL R-1/DR4, soluble Active Protein | TRAIL R-1/DR4 active protein
Human TRAIL R-1/DR4, soluble
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Ref.7
Subunit structure: Can interact with TRADD and RIPK1. Interacts with ARAP1. Ref.9
Subcellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.
Sequence similarities: Contains 1 death domain.Contains 3 TNFR-Cys repeats.
Research Articles on TRAIL R-1/DR4
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Product Notes
The TRAIL R-1/DR4 tnfrsf10a (Catalog #AAA692076) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human TRAIL R-1/DR4, soluble reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MSGTGAAAAT PSKVWGSSAG RIEPRGGGRG ALPTSMGQHG PSARAR AGRA PGPRPAREAS PRLRVHKTFK FVVVGVLLQV VPSSAATIKL H DQSIGTQQW EHSPLGELCP PGSHRSERPG ACNRCTEGVG YTNASQQ LFA CLPCTACKSD EEERSPCTTT RNTACQCKPG TFRNDNSAEM CR KCSTGCPR GMVKVKDCTP WSDIECVHKE SGNGHN. It is sometimes possible for the material contained within the vial of "TRAIL R-1/DR4, soluble, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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