Mouse Serum amyloid P Monoclonal Antibody | anti-APCS antibody

Serum amyloid P component antibody

• Gene Names: APCS; SAP; PTX2; HEL-S-92n
• Applications: ELISA, Western Blot, Immunoprecipitation
• Purity: Serum amyloid P component antibody was purified by ammonium sulfate precipitation
• Synonyms: Serum amyloid P; Monoclonal Antibody; Serum amyloid P component antibody; Monoclonal Serum amyloid P component; Anti-Serum amyloid P component; APCS; amyloid P component; serum; 9.5S alpha-1-glycoprotein; amyloid P component serum; serum protein; APCS amyloid P-component serum protein; BOS_2647; C-reactive protein; pentaxin-related; pentraxin; ptx2; Sap; serum amyloid P component; serum amyloid P-component; anti-APCS antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1 kappa
• Clone Number: 6E6
• Purity/Purification: Serum amyloid P component antibody was purified by ammonium sulfate precipitation
• Form/Format: Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol
• Sequence Length: 223

• Applicable Applications for anti-APCS antibody: ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: WB: 1:1000; IP: 1 ul
• Biological Significance: Serum amyloid P component (SAP) is a normal plasma protein and a universal non-fibrillar constituent of amyloid deposits. SAP is a member of the pentraxin protein family which includes C-reactive protein. Human SAP is secreted and catabolized only by hepatocytes, and consists of five identical non-covalently associated subunits, each with a molecular mass of 25 kDa, which are non-covalently associated in a pentameric disc-like ring. SAP is a calcium-dependent ligand binding protein, which binds to DNA and chromatin, and to all known types of amyloid fibrils accounting for its specific accumulation in amyloid deposits. Serum amyloid P component scintigraphy is a non-invasive and quantitative method for imaging amyloid deposits, which product images in most patients with systemic amyloidosis, and can be used repeatedly to monitor the course of the disease.
• Cross-Reactivity: Human
• Immunogen: Serum amyloid P component antibody was raised in Mouse using a protein purified from Human plasma as the immunogen
• Preparation and Storage: Aliquot and store for 1 year at -20 degree C, avoid freeze/thaw cycles

Western Blot (WB)

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Related Product Information for anti-APCS antibody

Mouse monoclonal Serum amyloid P component antibody

Product Categories/Family for anti-APCS antibody

Cell Biology

NCBI and Uniprot Product Information

• NCBI GI #: 4502133
• NCBI GeneID: 325
• NCBI Accession #: NP_001630.1
• NCBI GenBank Nucleotide #: NM_001639.3
• UniProt Accession #: P02743
• Molecular Weight: 25,387 Da
• NCBI Official Full Name: serum amyloid P-component
• NCBI Official Synonym Full Names: amyloid P component, serum
• NCBI Official Symbol: APCS
• NCBI Official Synonym Symbols: SAP; PTX2; HEL-S-92n
• NCBI Protein Information: serum amyloid P-component
• UniProt Protein Name: Serum amyloid P-component
• Protein Family: Serum amyloid P-component
• UniProt Gene Name: APCS
• UniProt Synonym Gene Names: PTX2; SAP
• UniProt Entry Name: SAMP_HUMAN

NCBI Description

The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]

Uniprot Description

APCS: Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits. Belongs to the pentaxin family.

Protein type: Chaperone; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q21-q23

Cellular Component: extracellular matrix; extracellular space; protein complex; extracellular region; nucleus

Molecular Function: complement component C1q binding; unfolded protein binding; virion binding; calcium ion binding; carbohydrate binding

Biological Process: protein folding; negative regulation of virion penetration into host cell; negative regulation of acute inflammatory response; acute-phase response; innate immune response; chaperone-mediated protein complex assembly; negative regulation of monocyte differentiation; negative regulation of viral reproduction