TGF-beta3 active protein
Human TGF-beta3
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]
Uniprot Description
Function: Involved in embryogenesis and cell differentiation.
Subunit structure: Homodimer; disulfide-linked. Interacts with ASPN. Ref.8
Subcellular location: Secreted.
Post-translational modification: The precursor is cleaved into mature TGF-beta-3 and LAP, which remains non-covalently linked to mature TGF-beta-3 rendering it inactive
By similarity.
Involvement in disease: Arrhythmogenic right ventricular dysplasia, familial, 1 (ARVD1) [MIM:107970]: A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10
Sequence similarities: Belongs to the TGF-beta family.
Sequence caution: The sequence CAA33024.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
Research Articles on TGF-beta3
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Product Notes
The TGF-beta3 tgfb3 (Catalog #AAA692039) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human TGF-beta3 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSG PCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY Y VGRTPKVEQ LSNMVVKSCK CS. It is sometimes possible for the material contained within the vial of "TGF-beta3, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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