Pleiotrophin Active Protein | PTN active protein
Human Pleiotrophin
Gene Names
PTN; HARP; HBNF; HBGF8; NEGF1
Reactivity
Human
Purity
> 98% by SDS-PAGE and HPLC analyses
Synonyms
Pleiotrophin; Human Pleiotrophin; Recombinant Human Pleiotrophin (PTN); PTN active protein
Host
E Coli
Reactivity
Human
Purity/Purification
> 98% by SDS-PAGE and HPLC analyses
Form/Format
Lyophilized
Sequence
GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GLGTREGTRT GAECKQ TMKT QRCKIPCNWK KQFGAECKYQ FQAWGECDLN TALKTRTGSL K RALHNAECQ KTVTISKPCG KLTKPKPQAE SKKKKKEGKK QEKMLD
Sequence Length
168
Endotoxin Level
< 0.1 ng per g of PTN
Biological Activity
Data not available.
Related Product Information for PTN active protein
Human Pleiotrophin (PTN) also called HARP (Heparin affin-regulatory peptide) is a new member of the heparin-binding neurotrophic factor family. PTN and Midkine are structural homologs, and are highly conserved among species. PTN plays an important role in development processes and promotion of neurite extension. Recombinant Pleiotrophin is a 15.4 kDa protein consisting of 136 amino acid residues.
Product Categories/Family for PTN active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
15.4 kDa
NCBI Official Full Name
pleiotrophin
NCBI Official Synonym Full Names
pleiotrophin
NCBI Official Symbol
PTN
NCBI Official Synonym Symbols
HARP; HBNF; HBGF8; NEGF1
NCBI Protein Information
pleiotrophin; HBBM; OSF-1; HB-GAM; HBGF-8; HBNF-1; osteoblast-specific factor 1; heparin-binding brain mitogen; heparin binding growth factor 8; heparin-binding growth factor 8; heparin affin regulatory protein; neurite growth-promoting factor 1; heparin-binding growth-associated molecule; heparin-binding neurite outgrowth-promoting factor 1; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)
UniProt Protein Name
Pleiotrophin
Protein Family
UniProt Gene Name
PTN
UniProt Synonym Gene Names
HBNF1; NEGF1; PTN; HBBM; HBGF-8; HB-GAM; HBNF-1; OSF-1
UniProt Entry Name
PTN_HUMAN
Uniprot Description
Function: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. Ref.3 Ref.17
Subunit structure: Interacts with ALK and NEK6. Ref.17 Ref.18
Subcellular location: Secreted.
Tissue specificity: Osteoblast and brain.
Induction: By heparin and retinoic acid. Ref.3 Ref.15
Post-translational modification: Phosphorylated by NEK6. Ref.18
Sequence similarities: Belongs to the pleiotrophin family.
Research Articles on PTN
Similar Products
Product Notes
The PTN ptn (Catalog #AAA691577) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human Pleiotrophin reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GLGTREGTRT GAECKQ TMKT QRCKIPCNWK KQFGAECKYQ FQAWGECDLN TALKTRTGSL K RALHNAECQ KTVTISKPCG KLTKPKPQAE SKKKKKEGKK QEKMLD. It is sometimes possible for the material contained within the vial of "Pleiotrophin, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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