Neuritin Active Protein | NRN1 active protein

Human Neuritin

Cat. Num. AAA691853

• Gene Names: NRN1; NRN; dJ380B8.2
• Reactivity: Human
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Synonyms: Neuritin; Human Neuritin; CPG15; NRN1; NRN1 active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: > 98% by SDS-PAGE & HPLC analyses
• Form/Format: Lyophilized
• Sequence: AGKCDAVFKG FSDCLLKLGD SMANYPQGLD DKTNIKTVCT YWEDFH SCTV TALTDCQEGA KDMWDKLRKE SKNLNIQGSL FELCGSGN
• Sequence Length: 142

• Biological Activity: Determined by a cell proliferation using rat C6 cells. The ED50 for this effect is 20.0-30.0 ng/ml.

Related Product Information for NRN1 active protein

Neuritin is a neurotrophic factor, which is expressed in response to induction of neuronal activity by NGF, BDNF, NT3, and other neural stimulators. It is expressed primarily in postmitotic-differentiating neurons of the developing nervous system and in neuronal structures related to synaptic plasticity in the adult nervous system. Neuritin acts as a molecular mediator of neurite outgrowth, neuronal survival, and synaptic maturation. Recombinant human Neuritin is a covalently disulfide-linked homodimer, consisting of two 9.72 kDa polypeptide monomers, each containing 88 amino acid residues.

Product Categories/Family for NRN1 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 525314165
• NCBI GeneID: 51299
• NCBI Accession #: NP_001265639.1
• NCBI GenBank Nucleotide #: NM_001278710.1
• UniProt Accession #: Q9NPD7; Q7Z4Y1; B2RA93
• Molecular Weight: 15,333 Da
• NCBI Official Full Name: neuritin isoform 1
• NCBI Official Synonym Full Names: neuritin 1
• NCBI Official Symbol: NRN1
• NCBI Official Synonym Symbols: NRN; dJ380B8.2
• NCBI Protein Information: neuritin
• UniProt Protein Name: Neuritin
• Protein Family: Neuritin
• UniProt Gene Name: NRN1
• UniProt Synonym Gene Names: NRN
• UniProt Entry Name: NRN1_HUMAN

NCBI Description

This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

Function: Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells

By similarity.

Subunit structure: Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing

By similarity.

Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor

Potential. Cell junction › synapse

By similarity.

Sequence similarities: Belongs to the neuritin family.